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Active Recombinant Mouse Vsig4 Protein, Fc Chimera

Cat.No. : Vsig4-861M
Product Overview : Recombinant Mouse Vsig4 (Accession # NP_808457), fused with , was produced in Mouse myeloma cell line, NS0-derived.
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Source : Mammalian cells
Species : Mouse
Tag : Fc
Predicted N Terminal : His20
Form : Lyophilized from a 0.2 µm filtered solution in PBS.
Bio-activity : Measured by its ability to inhibit anti-CD3-induced proliferation of splenic T lymphocytes. Vogt, L. et al. (2006) J. Clin. Invest. 116:2817.The presence of immobilized rmVSIG4/Fc Chimera inhibited the anti-CD3 response by 50% - 70%. The ED50 for this effect is typically 1.25 - 5 µg/mL.Measured by its ability to bind human iC3b in a functional ELISA. Optimal dilutions should be determined by each laboratory for each application.
Molecular Mass : Recombinant Mouse Vsig4, Fc Chimera has a calculated MW of 46 kDa (monomer). In SDS-PAGE migrates as 60-65 kDa, reducing conditions.
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Gene Name : Vsig4 V-set and immunoglobulin domain containing 4 [ Mus musculus ]
Official Symbol : Vsig4
Synonyms : VSIG4; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; complement receptor of the immunoglobulin superfamily; CRIg; Z39IG; BC025105; A530061A11; MGC36211;
Gene ID : 278180
mRNA Refseq : NM_177789
Protein Refseq : NP_808457
MIM :

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the relationship of VSIG4 to other genes or proteins? 08/18/2022

VSIG4 has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.

How can the disease be treated by regulating the levels of VSIG4? 05/09/2022

There are no drugs that directly regulate VSIG4 levels, but they can affect VSIG4 expression and function by modulating the immune system.

How to detect and analyze mutations in VSIG4? 02/08/2022

Mutations in VSIG4 can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

What is the specific role of VSIG4 in tumor immunity? 12/17/2020

VSIG4 plays an important role in tumor immunity, which can inhibit the activation and function of T cells and NK cells, thereby promoting tumor growth and metastasis.

How to study the regulatory mechanism of VSIG4? 06/05/2020

Studying the regulatory mechanism of VSIG4 requires a combination of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

What are the mutation types of VSIG4? 05/08/2020

The types of mutations in VSIG4 include point mutations, insertions/deletions, duplications, etc., which can cause structural and functional abnormalities of the protein.

Customer Reviews (3)

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Reviews
11/08/2021

    Stable performance, excellent performance in a variety of experiments.

    10/01/2021

      No side effects, high safety.

      03/13/2021

        It has good antigenicity and can induce target immune response.

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