Active Recombinant Rat Gdf11 protein
Cat.No. : | Gdf11-1080R |
Product Overview : | Recombinant Rat Gdf11(Asn299-Ser407) was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Source : | E. coli |
Species : | Rat |
Predicted N Terminal : | Met |
Form : | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein. |
Bio-activity : | Measured by its ability to induce hemoglobin expression in K562 human chronic myelogenous leukemia cells. Schwall, R.H. et al. (1991) Method Enzymol. 198:340. The ED50 for this effect is typically 0.8-4.8 ng/mL. |
Molecular Mass : | Predicted Molecular Mass12.6 (monomer) kDa |
Protein length : | Asn299-Ser407 |
Endotoxin : | <0.01 eu per 1 μg of the protein by the lal>0.01> |
Purity : | >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | Reconstitute at 100 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Gene Name : | Gdf11 growth differentiation factor 11 [ Rattus norvegicus ] |
Official Symbol : | Gdf11 |
Synonyms : | GDF11; growth differentiation factor 11; growth/differentiation factor 11; GDF-11; bone morphogenetic protein 11; BMP-11; |
Gene ID : | 29454 |
mRNA Refseq : | NM_017203 |
Protein Refseq : | NP_058899 |
MIM : | |
UniProt ID : | |
Chromosome Location : | 7q11 |
Function : | cytokine activity; growth factor activity; molecular_function; |
Products Types
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
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Q&As (6)
Ask a questionThe protein can be used to treat some diseases through stem cell therapy, such as using the promoter of GDF11 to activate the self-renewal and regenerative ability of stem cells.
GDF11 protein can be used as a therapeutic target for a variety of diseases such as muscular dystrophy, osteoporosis, cardiovascular diseases and neurodegenerative diseases.
GDF11 protein inhibits the differentiation of well-developed chondrocytes in bone growth plates into osteoblasts, thereby inhibiting bone growth.
The GDF11 protein can be intervened by means of drugs, such as using soluble GDF11 receptors to increase the activity of the GDF11 signaling pathway.
In young animals, GDF11 promotes muscle growth, but in older adults and mice, its effect is not significant.
This protein promotes the production and growth of neuroblasts and also plays an important role in the differentiation and function of neural stem cells.
Customer Reviews (3)
Write a reviewThe repeatability of GDF11 is very good, which can ensure the reliability of the experimental results, and also facilitate the subsequent research and application.
After using GDF11, my experimental results are more stable and reliable, and also convenient for subsequent data analysis.
The band intensity of GDF11 in Western blot was high, which improved the signal-to-noise ratio of the experiment.
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