Recombinant Human SYVN1, His & SUMO-tagged SYVN1-109H

Recombinant Human SYVN1, His & SUMO-tagged

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Recombinant Human SYVN1, His & SUMO-tagged

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Cat.No. : SYVN1-109H
Product Overview : Recombinant Human RFFL, fused with His6-SUMO, was expressed in E.coli. This construct is a Hrd1 N-terminal deletion containing residues 236-617 consisting of the complete C-terminal cytoplasmic portion. The N-terminal transmembrane spanning portion has been deleted. This Hrd1 N-terminal deletion mutant is active as an E3 ligase containing the RING and substrate recognition domains.
Source : E.coli
Species : Human
Tag : His & SUMO
Form : Dissolved in PBS, 10% glycerol
Bio-activity : Typical enzyme concentration 20nM -1 μM is used for in vitro conjugation depending on assay conditions.
Molecular Mass : 39.3 kDa (without SUMO tag)
Storage : Store at -80℃. Avoid repeated freeze/thaw cycles.
Gene Name : SYVN1 synovial apoptosis inhibitor 1, synoviolin [ Homo sapiens ]
Official Symbol : SYVN1
Synonyms : SYVN1; synovial apoptosis inhibitor 1, synoviolin; E3 ubiquitin-protein ligase synoviolin; HRD1; KIAA1810; MGC40372;
Gene ID : 84447
mRNA Refseq : NM_032431
Protein Refseq : NP_115807
MIM : 608046
UniProt ID : Q86TM6
Chromosome Location : 11q13
Pathway : Activation of Chaperone Genes by XBP1(S), organism-specific biosystem; Activation of Chaperones by IRE1alpha, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; HRD1/SEL1 ERAD complex, organism-specific biosystem; HRD1/SEL1 ERAD complex, conserved biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem;
Function : acid-amino acid ligase activity; ligase activity; metal ion binding; protein binding; zinc ion binding;

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