Recombinant Human TMIGD2 protein, Fc-tagged
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|Product Overview :||Recombinant Human TMIGD2 (Leu23-Gly150) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).|
|Description :||CD28 homolog (CD28H), also called transmembrane and immunoglobulin domain containing 2 (TMIGD2) and IGPR-1,is encoded by the TMIGD2 gene. CD28H is constitutively expressed on naive T and NK cells. After interaction of CD28 homolog with B7 homologue,the peripheral effector and memory T cells can be activated and proliferated by Akt-dependent signalling cascade. Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.|
|Tag :||human IgG1 Fc|
|Predicted N Terminal :||Leu23|
|Form :||Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.|
|Molecular Mass :||The protein has a calculated MW of 40.6 kDa. As a result of glycosylation, the protein migrates as 45-60 kDa under reducing (R) condition, and 90-120 kDa under non-reducing (NR) condition (SDS-PAGE).|
|Protein length :||Leu23-Gly150|
|Endotoxin :||Less than 1.0 EU per μg by the LAL method.|
|Purity :||>95% as determined by SDS-PAGE.|
For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|SDS-PAGE of TMIGD2-568H :||
Human CD28H, Fc Tag on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
|Bioactivity-ELISA of TMIGD2-568H :||
Immobilized Human B7-H7, His Tag at 5 μg/mL (100 μL/well) can bind Human CD28H, Fc Tag with a linear range of 1-20 ng/mL (QC tested).
|Gene Name :||TMIGD2|
|Official Symbol :||TMIGD2|
|Synonyms :||IGPR1; IGPR-1|
|Gene ID :||126259|
|mRNA Refseq :||NM_144615.2|
|Protein Refseq :||NP_653216.2|
|UniProt ID :||Q96BF3|
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