Recombinant Human TMIGD2 protein, Fc-tagged TMIGD2-568H

Recombinant Human TMIGD2 protein, Fc-tagged

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Recombinant Human TMIGD2 protein, Fc-tagged

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Cat.No. : TMIGD2-568H
Product Overview : Recombinant Human TMIGD2 (Leu23-Gly150) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).
Description : CD28 homolog (CD28H), also called transmembrane and immunoglobulin domain containing 2 (TMIGD2) and IGPR-1,is encoded by the TMIGD2 gene. CD28H is constitutively expressed on naive T and NK cells. After interaction of CD28 homolog with B7 homologue,the peripheral effector and memory T cells can be activated and proliferated by Akt-dependent signalling cascade. Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Source : HEK293
Species : Human
Tag : human IgG1 Fc
Predicted N Terminal : Leu23
Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 40.6 kDa. As a result of glycosylation, the protein migrates as 45-60 kDa under reducing (R) condition, and 90-120 kDa under non-reducing (NR) condition (SDS-PAGE).
Protein length : Leu23-Gly150
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
SDS-PAGE of TMIGD2-568H :

Human CD28H, Fc Tag on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA of TMIGD2-568H :

Immobilized Human B7-H7, His Tag at 5 μg/mL (100 μL/well) can bind Human CD28H, Fc Tag with a linear range of 1-20 ng/mL (QC tested).

Gene Name : TMIGD2
Official Symbol : TMIGD2
Synonyms : IGPR1; IGPR-1
Gene ID : 126259
mRNA Refseq : NM_144615.2
Protein Refseq : NP_653216.2
MIM : 614715
UniProt ID : Q96BF3

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