Active Recombinant Human FGFR1, Fc-tagged, Biotinylated
Cat.No. : | FGFR1-606H |
Product Overview : | The recombinant human FGFR1-Fc fusion protein is expressed as a 492 amino acid protein consisting of Arg22 - Glu285 region of FGFR1 (Uniprot accession #P11362 - isoform 15) and a C-terminal Fc fusion from human IgG1, which exists as a dimer under non-reducing condition. |
- Specification
- Gene Information
- Related Products
Source : | Human cells |
Species : | Human |
Tag : | Fc |
Form : | Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule). |
Bio-activity : | Binds and inhibits aFGF / FGF-acidic dependent proliferation of mouse fibroblast cells with an ED50 of 0.02 - 0.15 μg/mL |
Molecular Mass : | Calculated molecular mass (kDa): 55.0; Estimated by SDS-PAGE under reducing condition (kDa): 70-80 |
AA Sequence : | RPSPTLPEQDALPSSEDDDDDDDSS SEEKETDNTKPNPVAPYWTSPEKME KKLHAVPAAKTVKFKCPSSGTPNP TLRWLKNGKEFKPDHRIGGYKVRYA TWSIIMDSVVPSDKGNYTCIVENEY GSINHTYQLDVVERSPHRPILQAG LPANKTVALGSNVEFMCKVYSDPQP HIQWLKHIEVNGSKIGPDNLPYVQI LKTAGVNTTDKEMEVLHLRNVSFE DAGEYTCLAGNSIGLSHHSAWLTVL EALEERPAVMTSPLYLESTGTHTCP PCPAPELLGGPSVFLFPPKPKDTL MISRTPEVTCVVVDVSHEDPEVKFN WYVDGVEVHNAKTKPREEQYNSTYR VVSVLTVLHQDWLNGKEYKCKVSN KALPAPIEKTISKAKGQPREPQVYT LPPSREEMTKNQVSLTCLVKGFYPS DIAVEWESNGQPENNYKTTPPVL DSDGSFFLYSKLTVDKSRWQQGNVF SCSVMHEALHNHYTQKSLSLSPGK |
Endotoxin : | <0.1 eu per 1 μg of purified recombinant protein determined by the |
Purity : | >95% judged by SDS-PAGE under reducing condition |
Storage : | The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles. |
Gene Name : | FGFR1 fibroblast growth factor receptor 1 [ Homo sapiens ] |
Official Symbol : | FGFR1 |
Synonyms : | FGFR1; fibroblast growth factor receptor 1; FLT2, fms related tyrosine kinase 2 , KAL2; BFGFR; CD331; CEK; FLG; H2; H3; H4; H5; N SAM; Pfeiffer syndrome; FGFR1/PLAG1 fusion; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1; OGD; FLT2; KAL2; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; bFGF-R-1; FLJ99988; |
Gene ID : | 2260 |
mRNA Refseq : | NM_001174063 |
Protein Refseq : | NP_001167534 |
MIM : | 136350 |
UniProt ID : | P11362 |
Chromosome Location : | 8p12 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Downstream signaling of activated FGFR, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; |
Function : | ATP binding; fibroblast growth factor 1 binding; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; fibroblast growth factor-activated receptor activity; heparin binding; nucleotide binding; protein binding; protein homodimerization activity; protein tyrosine kinase activity; protein tyrosine kinase activity; receptor activity; |
Products Types
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FGFR1-28H | Recombinant Active Human FGFR1 (W666R) Mutant Protein, GST-tagged | +Inquiry |
FGFR1-1348H | Recombinant Human FGFR1 protein(Ala1-Lys221), hFc-tagged | +Inquiry |
◆ Lysates | ||
FGFR1-2133MCL | Recombinant Mouse FGFR1 cell lysate | +Inquiry |
FGFR1-2765HCL | Recombinant Human FGFR1 cell lysate | +Inquiry |
FGFR1-1171CCL | Recombinant Cynomolgus FGFR1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1590 | FGFR1 Functional Assay Kit | +Inquiry |
Kit-1557 | U2OS FGFR1 Bioassay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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