| Description : |
FGF R1 alpha, also known as fibroblast growth factor receptor 1 isoform 2, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. This protein is related fibroblast growth factor (FGF) receptors that are involved in physiological and pathological processes such as cell division, regulation of cell growth and maturation, formation of blood vessels and embryonic developments. The biological activities of the FGFs are meditated by a family of type 1 transmembrane tyrosine kinases which undergo dimerization and auto-phosphorylation after ligand binding. Also, this protein is thought to play an important role
in the development of the nervous system. It may also help regulate the growth of long bones, such as the large bones in the arms and legs. Defects in FGF R1 alpha are associated with various congenital malformations of the musculoskeletal system: these include the Pfeiffer syndrome, Jackson–Weiss syndrome, Antley-Bixler syndrome. Recombinant human FGF R1 alpha, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Source : |
Insect cell |
| Species : |
Human |
| Tag : |
His |
| Form : |
Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10 % glycerol. |
| Molecular Mass : |
40.1 kDa |
| Protein length : |
22-374 aa |
| AA Sequence : |
RPSPTLPEQA QPWGAPVEVE SFLVHPGDLL QLRCRLRDDV QSINWLRDGV QLAESNRTRI TGEEVEVQDS VPADSGLYAC VTSSPSGSDT TYFSVNVSDA LPSSEDDDDD DDSSSEEKET DNTKPNPVAP YWTSPEKMEK KLHAVPAAKT VKFKCPSSGT PNPTLRWLKN GKEFKPDHRI GGYKVRYATW SIIMDSVVPS DKGNYTCIVE NEYGSINHTY QLDVVERSPH RPILQAGLPA NKTVALGSNV EFMCKVYSDP QPHIQWLKHI EVNGSKIGPD NLPYVQILKT AGVNTTDKEM EVLHLRNVSF EDAGEYTCLA GNSIGLSHHS AWLTVLEALE ERPAVMTSPL YLELEHHHHH H |
| Endotoxin : |
< 1.0 EU per 1 ug of protein (determined by LAL method) |
| Purity : |
> 95 % by SDS - PAGE |
| Notes : |
For research use only. This product is not intended or approved for human, diagnostics or veterinary use. |
| Storage : |
Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 or -70 centigrade. Avoid repeated freezing and thawing cycles. |
| Concentration : |
0.5 mg/ml (determined by Absorbance at 280 nm) |
