Active Recombinant Human KDM6B, Flag-tagged

• Cat.No.: KDM6B-562H
• Product Overview: Recombinant Human KDM6B(a.a: 1043–end) fussed with Flag tag at C-terminal was expressed in Sf9 insect cells.

Specification

• Description: Human KDM6B also known as lysine (K)-specific demethylase 6B, plays a very improtant role in many path ways.
• Source: Insect cells
• Species: Human
• Tag: Flag
• Form: 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 90 µg/ml FLAG peptide, 10% glycerol, and 3 mM DTT.
• Bio-activity: 0.022 pmole/min/μg
• Molecular Mass: MW=71 kDa
• Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Stability: >6 months at –80 centigrade.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: KDM6B lysine (K)-specific demethylase 6B [ Homo sapiens ]
• Official Symbol: KDM6B
• Synonyms: JMJD3; lysine-specific demethylase 6B; jmjC domain-containing protein 3; jumonji domain containing 3, histone lysine demethylase; jumonji domain-containing protein 3; lysine demethylase 6B
• Gene ID: 23135
• mRNA Refseq: NM_001080424
• Protein Refseq: NP_001073893
• MIM: 611577
• UniProt ID: O15054
• Chromosome Location: 17p13.1
• Pathway: Cellular Senescence, organism-specific biosystem; Chromatin modifying enzymes, organism-specific biosystem; HDMs demethylate histones, organism-specific biosystem
• Function: beta-catenin binding; histone demethylase activity (H3-K27 specific); metal ion binding