Recombinant Human GFAP protein, MYC/DDK-tagged

• Cat.No.: GFAP-20H
• Product Overview: Recombinant Human GFAP, transcript variant 1, fussed with MYC/DDK tag at C-terminal was expressed in HEK293 cells.

Specification

• Description: This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
• Source: HEK293 cells
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 49.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: GFAP glial fibrillary acidic protein [ Homo sapiens ]
• Official Symbol: GFAP
• Synonyms: ALXDRD; glial fibrillary acidic protein
• Gene ID: 2670
• mRNA Refseq: NM_002055
• Protein Refseq: NP_002046
• MIM: 137780
• UniProt ID: P14136
• Chromosome Location: 17q21
• Pathway: Neural Crest Differentiation, organism-specific biosystem; Nuclear signaling by ERBB4, organism-specific biosystem; Signal Transduction, organism-specific biosystem
• Function: integrin binding; kinase binding; protein binding

Reviews

05/11/2022

Fast, efficient customer service.

12/12/2021

Product works great in assays.

07/16/2021

No problems, satisfied customer.

Q&As

What is the main function of GFAP in the central nervous system?

GFAP is crucial for maintaining the structure and function of astrocytes in the CNS.

How is GFAP used as a biomarker in neurological studies?

GFAP is used as a biomarker to assess astrocyte activation and neural damage.

How does GFAP contribute to the structure and support of astrocytes?

It forms intermediate filaments, providing mechanical support and stability to astrocytes.

What role does GFAP play in the response to brain injury?

It plays a protective role, participating in the glial scar formation post-injury.

How can dysregulation of GFAP affect neural function?

Dysregulation of GFAP can lead to impaired astrocyte function and neural dysfunction.

In which conditions is an increase in GFAP levels observed?

Increased GFAP levels are observed in gliosis, neurodegenerative diseases, and brain injuries.

Are there therapeutic interventions targeting GFAP for neurological disorders?

Therapeutic interventions may aim at modulating GFAP expression to mitigate neural damage.