Recombinant Mouse Gdf11 protein Gdf11-108M

Recombinant Mouse Gdf11 protein

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Recombinant Mouse Gdf11 protein

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Cat.No. : Gdf11-108M
Product Overview : Recombinant Mouse Gdf11 (299-407 aa) was expressed in E. coli.
Description : Bone morphogenetic proteins (BMP) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation. GDF11 is a circulating growth and differentiation factor that has age-dependent effects on development. Notably, injection of recombinant GDF11 into old mice, so that circulating levels match those in young mice, enhances vascularization in the brain, increases vessel volume, increases neural stem cell populations, and reverses cardiac hypertrophy. These changes mimic the changes in vascular remodeling, neurogenesis, and olfactory function that are produced by providing young blood to aged mice. In mouse embryos, GDF11 has critical roles in patterning mesodermal, skeletal, and neural tissues.
Source : E. coli
Species : Mouse
Form : Lyophilized. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Keep pH below 5.0. Do not vortex.
Bio-activity : Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 value for this effect is 0.08-0.1ug/ml.
Molecular Mass : 12.5 kDa
Purity : >90%
Stability : 1 year
Storage : Store at -80 centigrade
Gene Name : Gdf11 growth differentiation factor 11 [ Mus musculus ]
Official Symbol : Gdf11
Synonyms : growth/differentiation factor 11; GDF-11; bone morphogenetic protein 11
Gene ID : 14561
mRNA Refseq : NM_010272
Protein Refseq : NP_034402
UniProt ID : Q9Z1W4
Chromosome Location : 10; 10 D3
Function : cytokine activity; growth factor activity; protein binding

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