Active Recombinant Mouse Gdf11 protein

• Cat.No.: Gdf11-108M
• Product Overview: Recombinant Mouse Gdf11 (299-407 aa) was expressed in E. coli.

Specification

• Description: Bone morphogenetic proteins (BMP) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation. GDF11 is a circulating growth and differentiation factor that has age-dependent effects on development. Notably, injection of recombinant GDF11 into old mice, so that circulating levels match those in young mice, enhances vascularization in the brain, increases vessel volume, increases neural stem cell populations, and reverses cardiac hypertrophy. These changes mimic the changes in vascular remodeling, neurogenesis, and olfactory function that are produced by providing young blood to aged mice. In mouse embryos, GDF11 has critical roles in patterning mesodermal, skeletal, and neural tissues.
• Source: E. coli
• Species: Mouse
• Form: Lyophilized. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Keep pH below 5.0. Do not vortex.
• Bio-activity: Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 value for this effect is 0.08-0.1ug/ml.
• Molecular Mass: 12.5 kDa
• Purity: >90%
• Stability: 1 year
• Storage: Store at -80 centigrade

Gene Information

• Gene Name: Gdf11 growth differentiation factor 11 [ Mus musculus ]
• Official Symbol: Gdf11
• Synonyms: growth/differentiation factor 11; GDF-11; bone morphogenetic protein 11
• Gene ID: 14561
• mRNA Refseq: NM_010272
• Protein Refseq: NP_034402
• UniProt ID: Q9Z1W4
• Chromosome Location: 10; 10 D3
• Function: cytokine activity; growth factor activity; protein binding