Active Recombinant Human XCL1, HIgG1 Fc-tagged, mutant

• Cat.No.: XCL1-159H
• Product Overview: The extracellular domain of human XCL1 (AAH70309.1) (Val22-Gly114) is fused to the N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell.

Specification

• Description: This gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunologicalresponses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokinesubfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specificallychemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome1
• Source: CHO cell
• Species: Human
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to chemoattract BaF3 mouse pro B cells.
• Molecular Mass: 36KDa (monomer)
• AA Sequence: Val22-Gly114
• Endotoxin: <0.06 eu/μg as determined by lal>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.
• References: 1.Expression and function of the C-class chemokine lymphotactin (XCL1) in Wegener"s granulomatosis. 2.Interconversion between two unrelated protein folds in the lymphotactin native state.

Gene Information

• Gene Name: XCL1 chemokine (C motif) ligand 1 [ Homo sapiens ]
• Official Symbol: XCL1
• Synonyms: XCL1; chemokine (C motif) ligand 1; LTN, SCYC1, small inducible cytokine subfamily C, member 1 (lymphotactin); lymphotactin; ATAC; LPTN; SCM 1; SCM 1a; SCM-1-alpha; lymphotaxin; cytokine SCM-1; c motif chemokine 1; XC chemokine ligand 1; single cysteine motif 1a; small-inducible cytokine C1; small inducible cytokine subfamily C, member 1 (lymphotactin); LTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a
• Gene ID: 6375
• mRNA Refseq: NM_002995
• Protein Refseq: NP_002986
• MIM: 600250
• UniProt ID: P47992
• Chromosome Location: 1q24.2
• Pathway: Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; G alpha (q) signalling events, organism-specific biosystem
• Function: chemokine activity; chemokine receptor binding; chemokine receptor binding; protein homodimerization activity