"TNFRSF11B" Related Products

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Recombinant Human TNFRSF11B, Fc-tagged, Biotinylated

Cat.No.: TNFRSF11B-654H
Product Overview: The recombinant human OPG-Fc fusion is expressed as a 608 amino acid protein consisting of Glu22 - Leu401 region of OPG (UniProt accession #O00300) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.
Source: Human cells
Species: Human
Tag: Fc
Form: Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
Bio-activity: Binds to its ligands TRAIL and RANKL. Inhibits TRAIL- and RANKL-mediated signaling activity including NF-kB activation and TRAIL-induced cytotoxicity in L-929 mouse fibroblast cells.
Molecular Mass: Calculated molecular mass (kDa): 69.2; Estimated by SDS-PAGE under reducing condition (kDa): 75-85
Endotoxin: <0.1 eu per 1 μg of purified recombinant protein determined by the lal>
Purity: >95% judged by SDS-PAGE under reducing condition
Storage: The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name: TNFRSF11B tumor necrosis factor receptor superfamily, member 11b [ Homo sapiens ]
Official Symbol: TNFRSF11B
Synonyms: TNFRSF11B; tumor necrosis factor receptor superfamily, member 11b; OPG, osteoprotegerin; tumor necrosis factor receptor superfamily member 11B; OCIF; TR1; osteoprotegerin; osteoclastogenesis inhibitory factor; OPG; MGC29565;
Gene ID: 4982
mRNA Refseq: NM_002546
Protein Refseq: NP_002537
MIM: 602643
UniProt ID: O00300
Chromosome Location: 8q24
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Monoamine Transport, organism-specific biosystem; Osteoblast Signaling, organism-specific biosystem; Osteoclast Signaling, organism-specific biosystem; Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem;
Function: binding; cytokine activity; receptor activity;

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