Recombinant Canine PDCD1 protein, His-tagged PDCD1-384C

Recombinant Canine PDCD1 protein, His-tagged

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Recombinant Canine PDCD1 protein, His-tagged

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Cat.No. : PDCD1-384C
Product Overview : Recombinant Canine PDCD1(Met1-Leu169) fussed with His tag at C-terminal was expressed in HEK293.
Description : Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
Source : HEK293
Species : Canine
Tag : His
Predicted N Terminal : Leu 25
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
Molecular Mass : The recombinant canine PDCD1 consists 156 amino acids and predicts a molecular mass of 17.7 kDa.
Endotoxin : <1.0 EU per μg protein as determined by the LAL method.
Purity : > 85 % as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -70 centigrade
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : PDCD1 programmed cell death 1 [ Canis lupus familiaris ]
Official Symbol : PDCD1
Gene ID : 486213
Chromosome Location : chromosome: 25
Pathway : Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Costimulation by the CD28 family, organism-specific biosystem

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