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Recombinant Human MARCKS protein, MYC/DDK-tagged

Cat.No. : MARCKS-16H
Product Overview : Recombinant Human MARCKS fused with MYC/DDK tag at C-terminal was expressed in HEK293.
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Description : The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 31.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : MARCKS myristoylated alanine-rich protein kinase C substrate [ Homo sapiens ]
Official Symbol : MARCKS
Synonyms : MARCKS; myristoylated alanine-rich protein kinase C substrate; MACS, myristoylated alanine rich protein kinase C substrate (MARCKS, 80K L); myristoylated alanine-rich C-kinase substrate; 80K L; PKCSL; phosphomyristin; protein kinase C substrate, 80 kDa protein, light chain; myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L); MACS; 80K-L; PRKCSL; FLJ14368; FLJ90045;
Gene ID : 4082
mRNA Refseq : NM_002356
Protein Refseq : NP_002347
MIM : 177061
UniProt ID : P29966
Chromosome Location : 6q21
Pathway : Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem; Integration of energy metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Regulation of Insulin Secretion, organism-specific biosystem; Regulation of Insulin Secretion by Acetylcholine, organism-specific biosystem;
Function : actin filament binding; calmodulin binding; protein kinase C binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does MARCKS impact neurodegenerative diseases like Alzheimer's? 10/15/2021

MARCKS is involved in synaptic function and may contribute to the synaptic dysfunction observed in Alzheimer's disease.

Is MARCKS associated with inflammation? 03/10/2021

Yes, MARCKS is involved in inflammatory processes, and its dysregulation may contribute to inflammatory diseases.

Is MARCKS protein associated with neurological disorders? 01/02/2018

Yes, MARCKS has been linked to neurological disorders, and its dysregulation may contribute to conditions such as Alzheimer's disease.

Can MARCKS be a target for drug development? 07/17/2017

Yes, MARCKS is a potential target for drug development, particularly in conditions where its dysregulation contributes to disease progression.

Can targeting MARCKS be a strategy for cardiovascular disease treatment? 06/07/2017

Modulating MARCKS expression or activity may be considered as a therapeutic approach for certain cardiovascular conditions.

Customer Reviews (3)

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Reviews
07/21/2022

    MARCKS protein's ability to maintain structural integrity during imaging facilitates the detailed visualization of protein complexes and their interactions.

    03/23/2022

      researchers have found MARCKS protein to be highly suitable for protein electron microscopy structure analysis.

      12/27/2021

        MARCKS protein is highly recommended for research applications, particularly in ELISA assays and protein electron microscopy structure analysis.

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