Recombinant Human JAK1 protein, GST-tagged JAK1-18H

Recombinant Human JAK1 protein, GST-tagged

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Recombinant Human JAK1 protein, GST-tagged

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Cat.No. : JAK1-18H
Product Overview : Recombinant Human JAK1(438-end) fused with GST tag at N-terminal was expressed in Insect cells.
Description : JAK1 is a member of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. JAK1 bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. JAK1 plays an essential and nonredundant role in promoting biologic responses induced by a select subset of cytokine receptors, including those in which JAK utilization is thought to be nonspecific.
Source : Insect cells
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 22 nmol/min/mg
Molecular Mass : ~108 kDa
Purity : >75%
Applications : Kinase Assay, Western Blot
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 ug/ul
Gene Name : JAK1 Janus kinase 1 [ Homo sapiens ]
Official Symbol : JAK1
Synonyms : JAK1; Janus kinase 1; JAK1B; tyrosine-protein kinase JAK1; JAK1A; JTK3;
Gene ID : 3716
mRNA Refseq : NM_002227
Protein Refseq : NP_002218
MIM : 147795
UniProt ID : P23458
Chromosome Location : 1p32.3-p31.3
Pathway : Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem;
Function : ATP binding; growth hormone receptor binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein tyrosine kinase activity; protein tyrosine kinase activity;

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