Recombinant Human Histone Deacetylase 6, GST-tagged HDAC6-397H

Recombinant Human Histone Deacetylase 6, GST-tagged

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Recombinant Human Histone Deacetylase 6, GST-tagged

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Cat. No. : HDAC6-397H
Product Overview : Full Length Human HDAC6–Class IIb, 160kD with GST tag.
Description : Histone deacetylase 6, also known as HDAC6, is a human gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
Source : HDAC6 was cloned from human heart cDNA and expressed in insect cells using a baculoviral expression system.
Purity : Purified, active enzyme.
Purification Procedure : Glutathione Column
Activity : 1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug of protein at pH8 at 30°C.
Stability/Shelf-life : >6 months from date of shipment
Buffer Composition : 25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol.
Storage : –80°C
Gene Name : HDAC6 histone deacetylase 6 [ Homo sapiens ]
Synonyms : HDAC6; FLJ16239; HD6; JM21; histone deacetylase 6; OTTHUMP00000032398; EC 3.5.1.98; KIAA0901.
Gene ID : 10013
mRNA Refseq : NM_006044
Protein Refseq : NP_006035
MIM : 300272
UniProt ID : Q9UBN7
Chromosome Location : Xp11.23
Pathway : Gene Expression
Function : actin binding; histone deacetylase activity; histone deacetylase binding; hydrolase activity; metal ion binding; specific transcriptional repressor activity; tubulin deacetylase activity; zinc ion binding

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