|Cat. No. :
|Product Overview :
||Full Length Human HDAC6–Class IIb, 160kD with GST tag.
||Histone deacetylase 6, also known as HDAC6, is a human gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
||HDAC6 was cloned from human heart cDNA and expressed in insect cells using a baculoviral expression system.
||Purified, active enzyme.
|Purification Procedure :
||1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug of protein at pH8 at 30°C.
||>6 months from date of shipment
|Buffer Composition :
||25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol.