"IGFBP3" Related Products


Recombinant Human Insulin-like Growth Factor Binding Protein 3

Cat. No.: IGFBP3-80H
Product Overview: Recombinant Human IGFBP3 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 264 amino acids and having a molecular mass of 28806 Dalton. IGFBP-3 is purified by proprietary chromatographic techniques.
Description: IGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Source: Escherichia Coli.
Amino Acid sequence: The sequence of the first five N-terminal amino acids was determined and was found to be Gly-Ala-Ser-Ser-Gly.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Purity: Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation: The protein was lyophilized with 20mM Tris HCL.
Solubility: It is recommended to reconstitute the lyophilized Insulin-Like Growth Factor Binding Protein-3 in sterile 18 MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Specific Activity: The ED50, calculated by by its ability to inhibit IGF-II induced proliferation of MCF-7 is < 0.2µg/ml in the presence of 15ng/ml of Human IGF-II.
Stability: Lyophilized IBP3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGF-BP 3 should be stored at 4°Cbetween 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name: IGFBP3 insulin-like growth factor binding protein 3 [ Homo sapiens ]
Synonyms: IGFBP3; IGFBP-3; BP-53; IBP3; IBP-3; insulin-like growth factor binding protein 3; binding protein 29; binding protein 53; IGF-binding protein 3; acid stable subunit of the 140 K IGF complex; growth hormone-dependent binding protein; Growth-hormone-dependant binding protein
Gene ID: 3486
mRNA Refseq: NM_000598
Protein Refseq: NP_000589
MIM: 146732
UniProt ID: P17936
Chromosome Location: 7p13-p12
Pathway: p53 signaling pathway
Function: insulin-like growth factor I binding; metal ion binding; protein tyrosine phosphatase activator activity

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