||Recombinant Human Platelet-derived Growth Factor B mature chain produced inE.Coliis a non-glycosylated, polypeptide chain containing 109 amino acids fragment (82-190) and having with an amino-terminal His-tag. PDGF-B is purified by proprietary chromatographic techniques.
||The term 'PDGF' refers to a family of disulphide bond-linked dimeric isoforms that act as autocrine and paracrine growth factors and are produced by a variety of cell types other than platelets. They act as potent mitogens for almost all mesenchymally-derived cells. Aberrant expression is involved in certain cancers, fibroproliferative disorders and atherosclerosis. The protein also contributes to wound healing and neural regeneration. There are four members of the PDGF family-PDGF A, PDGF B, PDGF C and PDGF D. Two distinct types of PDGF-A exist-a short form that is soluble and a long form that is retained by the extracellular matrix.
||Sterile Filtered clear solution.
||Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
||Platelet-Derived Growth Factor-B is supplied in 1x PBS and 50% glycerol.
||Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.