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Recombinant Mouse BCL2-associated X Protein

Cat. No.: Bax-244M
Product Overview: Recombinant Mouse Bax produced inE.Coliis a single, non-glycosylated polypeptide chain. The Mouse Bax contains 133 (38-171) amino acids. The Mouse Bax is purified by proprietary romatographic techniques.
Description: The Bcl-2-associated X protein, or Bax is a protein of theBcl-2gene family. It promotesapoptosisby competing withBcl-2proper. Bax is a pro-apoptotic Bcl-2 protein containing BH1, BH2 and BH3 domains. In healthy mammalian cells, the majority of BAX is found in thecytosol, but upon initiation of apoptoticsignaling, Bax undergoes a conformation shift, and inserts intoorganellemembranes, primarily the outermitochondrialmembrane. Bax is believed to interact with, and induce the opening of the mitochondrial voltage-dependent anion channel,VDAC. Alternatively, growing evidence suggest that activated Bax and/orBakform an oligomeric pore,MACin the outer membrane. This result in the release ofcytochrome cand other pro-apoptotic factors from the mitochondria often referred to as mitochondrial outer membrane permeabilization, leading to activation ofcaspases.
Source: Escherichia Coli.
Physical Appearance: Sterile Filtered colorless solution.
Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.
Formulation: The protein, 200µg/ml contains 10mM Tris-HCL pH-8, 1mM EDTA and 250mM NaCl.
Other Available Varients: Recombinant Mouse BID, Recombinant Mouse tBID, Recombinant Mouse GST-BID Recombinant Mouse GST-Bax, Recombinant Mouse GST-Bax BH1, Recombinant Mouse GST-Bax BH2, Recombinant Mouse GST-Bax BH3, Recombinant Mouse GST-Bax IGDE, Recombinant Mouse GST-Bax D/A in IGDE.
Endotoxin: It is less than 0.1 ng/µg of rmBax.
Applications: Input marker or positive control (Western Blotting). Function study (binding assay).
Stability: The rMuBax although stable at 12°Cfor 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Gene Name: Bax BCL2-associated X protein [ Mus musculus ]
Synonyms: Bax; BCL2-associated X protein
Gene ID: 12028
mRNA Refseq: NM_007527
Protein Refseq: NP_031553
UniProt ID: Q07813
Chromosome Location: 7 B5; 7 23.0 cM
Pathway: Amyotrophic lateral sclerosis (ALS); Apoptosis; Colorectal cancer; Huntington"s disease; Huntington"s disease; Neurotrophin signaling pathway; Pathways in cancer; p53 signaling pathway; Prion diseases
Function: BH3 domain binding; protein binding; protein heterodimerization activity

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