Recombinant Mouse BCL2-associated X Protein

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Recombinant Mouse BCL2-associated X Protein

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Cat. No. : Bax-244M
Product Overview : Recombinant Mouse Bax produced inE.Coliis a single, non-glycosylated polypeptide chain. The Mouse Bax contains 133 (38-171) amino acids. The Mouse Bax is purified by proprietary romatographic techniques.
Description : The Bcl-2-associated X protein, or Bax is a protein of theBcl-2gene family. It promotesapoptosisby competing withBcl-2proper. Bax is a pro-apoptotic Bcl-2 protein containing BH1, BH2 and BH3 domains. In healthy mammalian cells, the majority of BAX is found in thecytosol, but upon initiation of apoptoticsignaling, Bax undergoes a conformation shift, and inserts intoorganellemembranes, primarily the outermitochondrialmembrane. Bax is believed to interact with, and induce the opening of the mitochondrial voltage-dependent anion channel,VDAC. Alternatively, growing evidence suggest that activated Bax and/orBakform an oligomeric pore,MACin the outer membrane. This result in the release ofcytochrome cand other pro-apoptotic factors from the mitochondria often referred to as mitochondrial outer membrane permeabilization, leading to activation ofcaspases.
Source : Escherichia Coli.
Physical Appearance : Sterile Filtered colorless solution.
Purity : Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.
Formulation : The protein, 200µg/ml contains 10mM Tris-HCL pH-8, 1mM EDTA and 250mM NaCl.
Other Available Varients : Recombinant Mouse BID, Recombinant Mouse tBID, Recombinant Mouse GST-BID Recombinant Mouse GST-Bax, Recombinant Mouse GST-Bax BH1, Recombinant Mouse GST-Bax BH2, Recombinant Mouse GST-Bax BH3, Recombinant Mouse GST-Bax IGDE, Recombinant Mouse GST-Bax D/A in IGDE.
Endotoxin : It is less than 0.1 ng/µg of rmBax.
Applications : Input marker or positive control (Western Blotting). Function study (binding assay).
Stability : The rMuBax although stable at 12°Cfor 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Based on PDB id 1F16. :

Gene Name : Bax BCL2-associated X protein [ Mus musculus ]
Synonyms : Bax; BCL2-associated X protein
Gene ID : 12028
mRNA Refseq : NM_007527
Protein Refseq : NP_031553
UniProt ID : Q07813
Chromosome Location : 7 B5; 7 23.0 cM
Pathway : Amyotrophic lateral sclerosis (ALS); Apoptosis; Colorectal cancer; Huntington"s disease; Huntington"s disease; Neurotrophin signaling pathway; Pathways in cancer; p53 signaling pathway; Prion diseases
Function : BH3 domain binding; protein binding; protein heterodimerization activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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