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Recombinant Human Troponin T Type 2 (Cardiac)

Cat. No.: TNNT2-221H
Product Overview: Recombinant Human TnT produced inE.Coliis a single, non-glycosylated, polypeptide chain. The TnT protein has a molecular mass of 40kDa. The TnT is purified by proprietary chromatographic techniques.
Description: A protein which in humans is encoded by the TNNT2 gene. The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with restrictiveand dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. Mutations of this gene may be associated with mild or absent hypertrophy and predominant restrictive disease, with a high risk of sudden cardiac death. Advancement to dilated cardiomyopathy may be more rapid in patients with TNNT2 mutations than in those with myosin heavy chain mutations.
Source: Escherichia Coli.
Physical Appearance: Sterile Filtered colourless liquid formualtion.
Formulation: Each mg of protein contains 50% glycerol.
Purity: Greater than 90.0% as determined by: (a) Analysis by RP-HPLC. (b) Anion-exchange FPLC. (c) Analysis by reducing and non-reducing SDS-PAGE Silver Stained.
Dimers And aggregates: Less than 1% as determined by silver-stained SDS-PAGE gel analysis.
Endotoxin: Endotoxin is less than 0.1 ng/µg of rHuTNC.
Applications: Immunoassays and western blot.
Stability: RHuTnT although stable at 10°Cfor 7 days, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Gene Name: TNNT2 troponin T type 2 (cardiac) [ Homo sapiens ]
Synonyms: TNNT2; troponin T type 2 (cardiac); CMH2; RCM3; TnTC; cTnT; CMPD2; MGC3889; troponin T2, cardiac; cardiomyopathy, hypertrophic 2;Cardiac muscle troponin T; Troponin T, cardiac muscle; TnTc; CMD1D; Cardiac muscle troponin T; cardiomyopathy, dilated 1D (autosomal dominant); troponin T type 2 (cardiac); troponin T type 2, cardiac; troponin T, cardiac muscle
Gene ID: 7139
mRNA Refseq: NM_000364
Protein Refseq: NP_000355
MIM: 191045
UniProt ID: P45379
Chromosome Location: 1q32
Pathway: Muscle contraction; Cardiac muscle contraction; Hypertrophic cardiomyopathy (HCM)
Function: actin binding; structural constituent of cytoskeleton; tropomyosin binding; troponin C binding; troponin I binding

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