Recombinant Human Cadherin 1, Type 1, E-cadherin (Epithelial)

• Cat.No.: CDH1-86H
• Product Overview: Recombinant Human Cadherin-E protein 600-707 a.a. expressed inE.coli,38 kDa.

Specification

• Cat. No.: CDH1-86H
• Description: E-cadherin (uvomorulin, cell-CAM120/80) is a calcium dependent cell adhesion molecule expressed predominately in epithelial tissues. It plays an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Numerous studies have demonstrated that reduction and/or loss of Ecadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
• Source: E.coli
• Sequence: iffcernpkpq viniidadlp pntspftael thgasanwti qyndptqesi ilkpkmalev gdykinlklm dnqnkdqvtt levsvcdceg aagvcrkaqp veaglqi
• Presentation: Recombinant Human Cadherin-E protein at 2µg/20µl in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
• Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 38 kDa.
• Applications: •ELISA •Inhibition Assays •Western Blotting
• Storage: Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months.

Gene Information

• Gene Name: CDH1 cadherin 1, type 1, E-cadherin (epithelial) [ Homo sapiens ]
• Synonyms: CDH1; cadherin 1, type 1, E-cadherin (epithelial); UVO; CDHE; ECAD; LCAM; Arc-1; CD324; cadherin 1, type 1; uvomorulin; cell-CAM 120/80; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial; uvomorulin; Cadherin-1; E-cadherin; CAM 120/80; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Uvomorulin; CD324 antigen; Epithelial cadherin
• Gene ID: 999
• mRNA Refseq: NM_004360
• Protein Refseq: NP_004351
• MIM: 192090
• UniProt ID: P12830
• Chromosome Location: 16q22.1
• Pathway: Adherens junction; Bladder cancer; Cell adhesion molecules (CAMs); Endometrial cancer; Melanoma; Pathogenic Escherichia coli infection - EHEC; Pathways in cancer; Thyroid cancer; Apoptosis; Cell-cell adhesion systems; Integrin cell surface interactions; Signaling in Immune system
• Function: RPTP-like protein binding; beta-catenin binding; calcium ion binding; cell adhesion molecule binding; protein phosphatase binding; transcription activator activity