Recombinant Human Desmin DES-113H

Recombinant Human Desmin

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Recombinant Human Desmin

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Cat. No. : DES-113H
Product Overview : Recombinant Human Desmin has a molecular mass of 53,539 dalton and is produced inE.Coli.
Description : This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.
Source : Escherichia Coli.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation : The protein was lyophilized from a 1mg/ml solution containing 30 mM Tris/HCI pH 8, 9.5 M urea, 2 mM DTT, 2 mM EDTA and 10 mM methylammonium chloride.
Purity : Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Solubility : It is recommended to reconstitute the lyophilized rHuDesmin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability : Lyophilized rHuDesmin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuDesmin should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : DES desmin [ Homo sapiens ]
Synonyms : DES; desmin; CSM1; CSM2; CMD1I; FLJ12025; FLJ39719; FLJ41013; FLJ41793; intermediate filament protein; OTTHUMP0000 0064865
Gene ID : 1674
mRNA Refseq : NM_001927
Protein Refseq : NP_001918
UniProt ID : P17661
Chromosome Location : 2q35
MIM : 125660
Pathway : Arrhythmogenic right ventricular cardiomyopathy (ARVC); Hypertrophic cardiomyopathy (HCM); Muscle contraction
Function : protein binding; structural constituent of cytoskeleton

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