"DES" Related Products

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Recombinant Human Desmin

Cat. No.: DES-113H
Product Overview: Recombinant Human Desmin has a molecular mass of 53,539 dalton and is produced inE.Coli.
Description: This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.
Source: Escherichia Coli.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation: The protein was lyophilized from a 1mg/ml solution containing 30 mM Tris/HCI pH 8, 9.5 M urea, 2 mM DTT, 2 mM EDTA and 10 mM methylammonium chloride.
Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Solubility: It is recommended to reconstitute the lyophilized rHuDesmin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability: Lyophilized rHuDesmin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuDesmin should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name: DES desmin [ Homo sapiens ]
Synonyms: DES; desmin; CSM1; CSM2; CMD1I; FLJ12025; FLJ39719; FLJ41013; FLJ41793; intermediate filament protein; OTTHUMP0000 0064865
Gene ID: 1674
mRNA Refseq: NM_001927
Protein Refseq: NP_001918
UniProt ID: P17661
Chromosome Location: 2q35
MIM: 125660
Pathway: Arrhythmogenic right ventricular cardiomyopathy (ARVC); Hypertrophic cardiomyopathy (HCM); Muscle contraction
Function: protein binding; structural constituent of cytoskeleton

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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