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Recombinant Human S100 Calcium Binding Protein A7

Cat. No.: S100A7-431H
Product Overview: Recombinant Human full length S100A7 (S100 calcium-binding protein A7, psoriasin) cloned from human cDNA was expressed inE.coli. The protein consists of the human S100A7 swissprot accession Q5SY67. MW = 22.9 kDa (dimer).
Description: Protein S100-A7 is a protein that in humans is encoded by the S100A7 gene. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The protein functions as a prominent antimicrobial peptide mainly against E.coli.
Source: E.Coli.
Purity: > 95% by SDS-PAGE. The protein runs as a monomer giving a single band migrating at a molecular weight of <14 kDa.
Supplied As: 2mg/ml in Mes 30mM KCl 150 mM, pH 6.5. The concentration is calculated from the absorbance at 280nm (e280 = 4400 M-1 cm-1).
Characteristics: Under the above described conditions, to avoid precipitation, the product can be concentrated to a maximum of 0.4mM (dimer).
Storage: -20º C. The protein is stable at 4 ºC for at least 2 weeks and at 25 ºC for at least 1 day. After initial defrost, aliquot product into individual tubes and refreeze at -20º C. Avoid repeated freeze/defrost cycles.
Gene Name: S100A7 S100 calcium binding protein A7 [ Homo sapiens ]
Synonyms: S100A7; S100 calcium binding protein A7; PSOR1; S100A7c; S100A7; S100 calcium-binding protein A7 (psoriasin 1); S100 calcium binding protein A7 (psoriasin 1); psoriasin 1; OTTHUMP00000015328; OTTHUMP00000015327
Gene ID: 6278
mRNA Refseq: NM_002963
Protein Refseq: NP_002954
MIM: 600353
UniProt ID: P31151
Chromosome Location: 1q21
Function: calcium ion binding; protein binding; zinc ion binding

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