"TNFSF13B" Related Products

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Recombinant Human TNFSF13B

Cat. No.: TNFSF13B-63H
Product Overview: Recombinant Human tumor necrosis factor (ligand) encoding the human BAFF protein sequence (containing the signal peptide sequence and the mature BAFF sequence) was expressed in modifiedhuman 293 cells.
Description: BAFF is a type II membrane glycoprotein expressed by T cells, dendritic cells, macrophages and neutrophils. BAFF is predominantly a B cell survival factor and specifically promotes the proliferation and survival of activated B cells by inducing expression of pro-survival oncogenes including Bcl-xL, Bcl-2 and Mcl-1. BAFF also mediates Ig switching to IgD as well as B cell maturation, suggesting it plays a role in humoral immune responses.
Source: Human 293 cells.
Amino Acid Sequence: AVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL.
Molecular Mass: BAFFB migrates as a band between 15 and 20 kDa in SDS-PAGE. This compares with the predicted molecular mass of 17 kDa.
pI: Due to post-translational modifications the Symansis BAFFB separates into a number of glycoforms with a pI between 4.7 and 5.5 on 2D PAGE. This is in agreement with the unmodified BAFF that has a predicted pI of 4.9.
Purity: >95%, as determined by SDS-PAGE and visualized by Coomassie Brilliant Blue.
Formulation: When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Reconstitution: It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Storage: Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, with longer-term storage in aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
Activity: The ED50of BAFFB is typically 5-10 ng/ml as measured by its ability to neutralise dexamethasone toxicity using the RPMI 8226 cell line.
Gene Name: TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b [ Homo sapiens ]
Synonyms: TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b; DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20; TNFSF13B;Tumor necrosis factor ligand superfamily member 13B;TNF- and APOL-related leukocyte expressed ligand 1; B lymphocyte stimulator; B cell-activating factor; Dendritic cell-derived TNF-like moleculeCD_antigen=CD257;Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosisfactor ligand superfamily member 13b, soluble form
Gene ID: 10673
mRNA Refseq: NM_001145645
Protein Refseq: NP_001139117
UniProt ID: Q9Y275
Chromosome Location: 13q32-q34
MIM: 603969
Pathway: Cytokine-cytokine receptor interaction
Function: cytokine activity; tumor necrosis factor receptor binding

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