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Active Recombinant Human CD40, Fc Chimera

Cat.No. : CD40-493H
Product Overview : Recombinant Human CD40 encoding the signal peptide and extracellular domain of human CD40 (aa 1-193) was fused to the Fc region of human IgG1 (aa 90-330). The chimeric protein was expressed in modifiedHuman 293 cells.
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Cat. No. : CD40-493H
Description : CD40 (TNFRSF5, CD40L Receptor) is a type I membrane protein and a member of the TNF receptor family. CD40 is expressed on B cells, monocytes, dendritic cells, endothelial cells, epithelial cells and B cell lymphomas and carcinomas. CD40 activates mulitple signalling pathways and can promote cell survival through up-regulation of the expression of genes encoding anti-apoptopic proteins.
Source : Human 293 cells.
Amino Acid Sequence : EPPTACREKQYLINSQCCSLCQPGQ KLVSDCTEFTETECLPCGESEFLDT WNRETHCHQHKYCDPNLGLRVQQKG TSETDTICTCEEGWHCTSEACESCV LHRSCSPGFGVKQIATGVSDTICEP CPVGFFSNVSSAFEKCHPWTSCETK DLVVQQAGTNKTDVVCGPQDRLRRS SNTKVDKKVEPKSCDKTHTCPPCPA PELLGGPSVFLFPPKPKDTLMISRT PEVTCVVVDVSHEDPEVKFNWYVDG VEVHNAKTKPREEQYNSTYRVVSVL TVLHQDWLNGKEYKCKVSNKALPAP IEKTISKAKGQPREPQVYTLPPSRD ELTKNQVSLTCLVKGFYPSDIAVEW ESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK.
Molecular Mass : Under reducing conditions CD40 (173aa) – Fc Chimera migrates as a broad band between 50 and 65 kDa on SDS-PAGE due to post-translational modifications, in particular glycosylation.
pI : CD40 (173aa) – Fc Chimera separates into a number of glycoforms with an observed pI between 5.5 and 9.0 in 2D PAGE due to post-translational modifications, in particular glycosylation.
% Carbohydrate : Purified CD40 (173aa) - Fc Chimera consists of 5 to 30% carbohydrate by weight.
Glycosylation : CD40 (173aa) – Fc Chimera contains N-linked oligosaccharides and may contain O-linked oligosaccharides.
Purity : >95%, as determined by SDS-PAGE and visualized by Coomassie Brilliant Blue.
Formulation : When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Reconstitution : It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Storage : Lyophilized products should be stored at 2 to 8°C.
Activity : The ED50of CD40 (173aa) – Fc Chimera is typically 1.0-1.5 ug/ml as measured by its ability to neutralize CD40 ligand mediated proliferation of T47-D cells.
Gene Name : CD40 CD40 molecule, TNF receptor superfamily member 5 [ Homo sapiens ]
Synonyms : CD40; CD40 molecule, TNF receptor superfamily member 5; p50; Bp50; CDW40; MGC9013; TNFRSF5; CD40 antigen; CD40 type II isoform; CD40L receptor; B cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); nerve growth factor receptor-related B-lymphocyte activation molecule; tumor necrosis factor receptor superfamily, member 5;B-cell surface antigen CD40; OTTHUMP00000031699; OTTHUMP 00000031700
Gene ID : 958
mRNA Refseq : NM_001250
Protein Refseq : NP_001241
UniProt ID : P25942
Chromosome Location : 20q12-q13.2
MIM : 109535
Pathway : ograft rejection; Autoimmune thyroid disease; Cell adhesion molecules (CAMs); Cytokine-cytokine receptor interaction; Primary immunodeficiency; Systemic lupus erythematosus; Toll-like receptor signaling pathway; Signaling in Immune system
Function : enzyme binding; receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Can CD40-targeted therapies be used in the treatment of infectious diseases? 05/31/2022

CD40 agonists have the potential to enhance immune responses against infectious agents, but their clinical use in this context is an area of ongoing research.

Are there any approved drugs targeting CD40 for clinical use? 05/07/2021

As of my knowledge cutoff date in January 2022, there were no FDA-approved drugs specifically targeting CD40. However, clinical trials were ongoing for CD40-targeted therapies.

Can CD40-targeted therapies be used in combination with other cancer treatments? 04/24/2019

Yes, CD40-targeted therapies are often investigated in combination with other treatments like checkpoint inhibitors or chemotherapy to enhance their effectiveness.

What are the potential side effects of CD40-targeted therapies in cancer treatment? 09/25/2018

Side effects may include flu-like symptoms, cytokine release syndrome, and immune-related adverse events, which can be managed with supportive care and close monitoring.

Are there ongoing clinical trials exploring CD40-targeted therapies for atherosclerosis? 04/25/2017

Research on CD40-targeted therapies for atherosclerosis is still in the experimental stages and not yet in advanced clinical trials.

Customer Reviews (3)

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Reviews
10/28/2021

    Its utilization in this technique has allowed for precise visualization and determination of protein structures with remarkable clarity and resolution.

    08/11/2021

      The reliable and high-quality results obtained using CD40 protein make it an excellent choice for researchers studying protein structures.

      10/07/2018

        CD40 protein has proved to be an invaluable tool in protein electron microscopy structure analysis.

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