Recombinant Human CSF3R, Fc Chimera CSF3R-164H

Recombinant Human CSF3R, Fc Chimera

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Recombinant Human CSF3R, Fc Chimera

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Cat. No. : CSF3R-164H
Product Overview : Recombinant Human colony stimulating factor 3 receptor (granulocyte) encoding the signal peptide and extracellular domain of human colony stimulating factor 3 receptor (granulocyte) (aa 1-621) was fused to the Fc region of human IgG1 (aa 90-330). The chimeric protein was expressed in modifiedhuman 293 cells.
Description : Colony stimulating factor 3 receptor (granulocyte), also known as granulocyte colony-stimulating factor receptor and CD114 antigen, is a member of the cytokine receptor superfamily. Members of this family, which also includes the receptors for IL-2 to IL-7, GM-CSF, EPO, TPO and GH, are characterised by the presence of four conserved cysteine residues in their extracellular domains.
Source : Human 293 cells.
Amino Acid Sequence : ECGHISVSAPIVHLG DPITASCIIKQNCSH LDPEPQILWRLGAEL QPGGRQQRLSDGTQE SIITLPHLNHTQAFL SCCLNWGNSLQILDQ VELRAGYPPAIPHNL SCLMNLTTSSLICQW EPGPETHLPTSFTLK SFKSRGNCQTQGDSI LDCVPKDGQSHCCIP RKHLLLYQNMGIWVQ AENALGTSMSPQLCL DPMDVVKLEPPMLRT MDPSPEAAPPQAGCL QLCWEPWQPGLHINQ KCELRHKPQRGEASW ALVGPLPLEALQYEL CGLLPATAYTLQIRC IRWPLPGHWSDWSPS LELRTTERAPTVRLD TWWRQRQLDPRTVQL FWKPVPLEEDSGRIQ GYVVSWRPSGQAGAI LPLCNTTELSCTFHL PSEAQEVALVAYNSA GTSRPTPVVFSESRG PALTRLHAMARDPHS LWVGWEPPNPWPQGY VIEWGLGPPSASNSN KTWRMEQNGRATGFL LKENIRPFQLYEIIV TPLYQDTMGPSQHVY AYSQEMAPSHAPELH LKHIGKTWAQLEWVP EPPELGKSPLTHYTI FWTNAQNQSFSAILN ASSRGFVLHGLEPAS LYHIHLMAASQAGAT NSTVLTLMTLTPRSS NTKVDKKVEPKSCDK THTCPPCPAPELLGG PSVFLFPPKPKDTLM ISRTPEVTCVVVDVS HEDPEVKFNWYVDGV EVHNAKTKPREEQYN STYRVVSVLTVLHQD WLNGKEYKCKVSNKA LPAPIEKTISKAKGQ PREPQVYTLPPSRDE LTKNQVSLTCLVKGF YPSDIAVEWESNGQP ENNYKTTPPVLDSDG SFFLYSKLTVDKSRW QQGNVFSCSVMHEAL HNHYTQKSLSLSPGK .
Molecular Mass : Under reducing conditions Colony stimulating factor 3 receptor – Fc Chimera migrates as a broad band between 100 and 130 kDa in SDS-PAGE due to post-translation modifications, in particular glycosylation.
pI : The unmodified Colony stimulating factor 3 receptor - Fc Chimera has a predicted pI of 6.6.
% Carbohydrate : Purified Colony stimulating factor 3 receptor - Fc Chimera consists of 5-30% carbohydrate by weight.
Glycosylation : Colony stimulating factor 3 receptor Fc Chimera contains N-linked oligosacch arides and may contain O-linked oligosaccharides.
Purity : >95%, as determined by SDS-PAGE and visualized by silver stain.
Formulation : When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Storage : Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
PDB rendering based on 2d9q. :

Gene Name : CSF3R colony stimulating factor 3 receptor (granulocyte) [ Homo sapiens ]
Synonyms : CSF3R; colony stimulating factor 3 receptor (granulocyte); CD114; GCSFR; colony stimulating factor 3 receptor; CD114; antigenOTTHUMP00000009703; antigenOTTHUMP00000009704; antigenOTTHUMP00000009705; granulocyte colony stimulating factor receptor
Gene ID : 1441
mRNA Refseq : NM_000760
Protein Refseq : NP_000751
UniProt ID : Q99062
Chromosome Location : 1p35-p34.3
MIM : 138971
Pathway : Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway; Pathways in cancer
Function : cytokine receptor activity; otein binding; receptor activity

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