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Recombinant Human CSF3R, Fc Chimera

Cat. No.: CSF3R-164H
Product Overview: Recombinant Human colony stimulating factor 3 receptor (granulocyte) encoding the signal peptide and extracellular domain of human colony stimulating factor 3 receptor (granulocyte) (aa 1-621) was fused to the Fc region of human IgG1 (aa 90-330). The chimeric protein was expressed in modifiedhuman 293 cells.
Description: Colony stimulating factor 3 receptor (granulocyte), also known as granulocyte colony-stimulating factor receptor and CD114 antigen, is a member of the cytokine receptor superfamily. Members of this family, which also includes the receptors for IL-2 to IL-7, GM-CSF, EPO, TPO and GH, are characterised by the presence of four conserved cysteine residues in their extracellular domains.
Source: Human 293 cells.
Amino Acid Sequence: ECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPRSSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK.
Molecular Mass: Under reducing conditions Colony stimulating factor 3 receptor – Fc Chimera migrates as a broad band between 100 and 130 kDa in SDS-PAGE due to post-translation modifications, in particular glycosylation.
pI: The unmodified Colony stimulating factor 3 receptor - Fc Chimera has a predicted pI of 6.6.
% Carbohydrate: Purified Colony stimulating factor 3 receptor - Fc Chimera consists of 5-30% carbohydrate by weight.
Glycosylation: Colony stimulating factor 3 receptor Fc Chimera contains N-linked oligosacch arides and may contain O-linked oligosaccharides.
Purity: >95%, as determined by SDS-PAGE and visualized by silver stain.
Formulation: When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Storage: Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
Gene Name: CSF3R colony stimulating factor 3 receptor (granulocyte) [ Homo sapiens ]
Synonyms: CSF3R; colony stimulating factor 3 receptor (granulocyte); CD114; GCSFR; colony stimulating factor 3 receptor; CD114; antigenOTTHUMP00000009703; antigenOTTHUMP00000009704; antigenOTTHUMP00000009705; granulocyte colony stimulating factor receptor
Gene ID: 1441
mRNA Refseq: NM_000760
Protein Refseq: NP_000751
UniProt ID: Q99062
Chromosome Location: 1p35-p34.3
MIM: 138971
Pathway: Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway; Pathways in cancer
Function: cytokine receptor activity; otein binding; receptor activity

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