"DFFA" Related Products

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Recombinant Human DFFA

Cat. No.: DFFA-488H
Product Overview: Recombinant DFFA protein was expressed inE.coliand purified by using conventional chromatography techniques. MW=38.7 kDa (351aa).
Description: DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA, also known as DNA fragmentation factor subunit alpha, is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.
Source: E.coli.
Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MEVTGDAGVP ESGEIRTLKP CLLRRNYSRE QHGVAASCLE DLRSKACDIL AIDKSLTPVT LVLAEDGTIV DDDDYFLCLP SNTKFVALAS NEKWAYNNSD GGTAWISQES FDVDETDSGA GLKWKNVARQ LKEDLSSIIL LSEEDLQMLV DAPCSDLAQE LRQSCATVQR LQHTLQQVLD QREEVRQSKQ LLQLYLQALE KEGSLLSKQE ESKAAFGEEV DAVDTGISRE TSSDVALASH ILTALREKQA PELSLSSQDL ELVTKEDPKA LAVALNWDIK KTETVQEACE WELALRLQQT QSLHSLRSIS ASKASPPGDL QNPKRARQDP T.
Form: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol 1mM DTT.
Purity: > 90% by SDS – PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: DFFA DNA fragmentation factor, 45kDa, alpha polypeptide [ Homo sapiens ]
Synonyms: DFFA; DNA fragmentation factor, 45kDa, alpha polypeptide; DFF1; ICAD; DFF-45; DFF45; ICAD; DFF1; DNA fragmentation factor subunit alpha; DNA fragmentation factor 45 kDa subunit; Inhibitor of CAD; DFF45; H13; OTTHUMP00000001903; OTTHUMP00000001904; DNA fragmentation factor, 45 kD, alpha subunit
Gene ID: 1676
mRNA Refseq: NM_004401
Protein Refseq: NP_004392
MIM: 601882
UniProt ID: O00273
Chromosome Location: 1p36.3-p36.2
Pathway: Apoptosis
Function: caspase-activated deoxyribonuclease activity; identical protein binding

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