"GRB2" Related Products

Expand
Expand
Expand

Recombinant Human Growth Factor Receptor-bound Protein 2, His-tagged

Cat. No.: GRB2-500H
Product Overview: Recombinant human GRB2 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography. MW = 27kDa.
Description: Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. GRB2 is widely expressed and also binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Grb2 is composed of an SH2 domain flanked on each side by an SH3 domain. Inhibition of Grb2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various cell types.
Source: E.Coli.
Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV.
From: Liquid. In 20mM Tris-HCl (pH8.0) buffer containing 30% glycerol.
Purity: > 95% by SDS–PAGE.
Concentration: 1mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: GRB2 growth factor receptor-bound protein 2 [ Homo sapiens ]
Synonyms: GRB2; growth factor receptor-bound protein 2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; Adapter protein GRB2; SH2/SH3 adapter GRB2; Protein Ash; HT027; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2; abundant SRC homology ; OTTHUMP00000166096; OTTHUMP00000166097; OTTHUMP00000166098
Gene ID: 2885
mRNA Refseq: NM_002086
Protein Refseq: NP_002077
MIM: 108355
UniProt ID: P62993
Chromosome Location: 17q24-q25
Pathway: Acute myeloid leukemia; B cell receptor signaling pathway; Chemokine signaling pathway; Chronic myeloid leukemia; Colorectal cancer; Dorso-ventral axis formation; ErbB signaling pathway; Endometrial cancer; Focal adhesion; Fc epsilon RI signaling pathway; Gap junction; Glioma; GnRH signaling pathway; Insulin signaling pathway; Jak-STAT signaling pathwayV; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Non-small cell lung cancer; Pathways in cancer; Prostate cancer; Renal cell carcinoma; T cell receptor signaling pathway
Function: SH3/SH2 adaptor activity; epidermal growth factor receptor binding; insulin receptor substrate binding; phosphoprotein binding; phosphotyrosine binding; protein domain specific binding

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.