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Recombinant Human Ubiquitin-conjugating Enzyme E2L 3

Cat.No. : UBE2L3-33H
Product Overview : Recombinant Human UbcH7(154amino acid) was over-expressed inE.coliand purified by using conventional chromatography techniques. MW = 17.9 kDa (154 aa).
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Cat. No. : UBE2L3-33H
Description : Human Ubquitin-conjugating enzyme 7(UbcH7) is a ubiquitin-conjugating enzyme (E2) mediating c-fos degradation, transcription factor NF-B maturation, and human papilloma virus-mediated p53 and Myc protein degradation, in vitro. The ubiquitin-conjugating enzymes(E2s) are essential components of the post-translational protein ubiquitination pathway, mediating the transfer of activated ubiquitin to substrate proteins. The human UBE2L1-UBE2L4 gene could potentially encode different isoforms of the UbcH7. UBE2L3 gene, located at chromosome 22q11.2, is the only identical family member with introns and encodes a polypeptide sequence identical to that of UbcH7.
Source : E.coli.
Amino Acid Sequence : MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA FRIEINFPAE YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQVIQSLIA LVNDPQPEHP LRADLAEEYS KDRKKFCKNA EEFTKKYGEK RPVD
Form : Liquid. In 50 mM HEPES (pH 7.5) containing 150 mM NaCl 1 mM DTT and 10% glycerol.
Purity : > 95% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : UBE2L3 ubiquitin-conjugating enzyme E2L 3 [ Homo sapiens ]
Synonyms : E2-F1; L-UBC; UBCH7; UbcM4; ubiquitin-conjugating enzyme E2L 3; UB2L3_HUMAN; EC 6.3.2.19; Ubiquitin-protein ligase L3;Ubiquitin carrier protein L3; UBCE7; ubiquitin carrier protein; ubiquitin-conjugating enzyme E2L3; ubiquitin-conjugating enzyme UBCH7; ubiquitin-protein ligase; UBE2L3
Gene ID : 7332
mRNA Refseq : NM_003347
Protein Refseq : NP_003338
MIM : 603721
UniProt ID : P68036
Chromosome Location : 22q11.21
Pathway : Parkinson"s disease
Function : enzyme binding; ligase activity; small conjugating protein ligase activity; ubiquitin-protein ligase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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