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Active Recombinant Human FCGR2A protein(167 Arg), His-tagged

Cat.No. : FCGR2A-649H
Product Overview : Recombinant Human FCGR2A protein (Met1-Ile218) (P12318-1, with Natural variant His 167 Arg), fused with a C-terminal polyhistidine tag, was expressed in HEK293.
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Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from sterile PBS, pH 7.5
Normally 5 % trehalose, 5 % mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Bio-activity : 1. Measured by its ability to bind biotinylated human IgG2 in functional ELISA.
2. Loaded Anti-CD32A Antibody, Mouse Monoclonal on AMC Biosensor, can bind CD32A Protein, Human, Recombinant (167 Arg, His Tag) with an affinity constant of 6.8 nM as determined by Octet RED System.
Molecular Mass : The recombinant human FCGR2A consists of 196 amino acids after removal of the signal peptide and predicts a molecular mass of 22 kDa. It migrates as an approximately 30 kDa protein due to glycosylation by SDS-PAGE under reducing conditions.
Protein length : Met1-Ile218
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 97 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) [ Homo sapiens ]
Official Symbol : FCGR2A
Synonyms : FCGR2A; CD32; CD32A; CDw32; IGFR2; fcRII-a; fc-gamma-RIIa; FCG2; FcGR; FCGR2; FCGR2A1; MGC23887; MGC30032;
Gene ID : 2212
mRNA Refseq : NM_001136219.1
Protein Refseq : NP_001129691.1
MIM : 146790
UniProt ID : P12318

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does FCGR2A impact the risk and severity of certain allergic reactions? 03/22/2023

FCGR2A may influence the risk and severity of allergic reactions by modulating the immune response to allergens and antibodies involved in allergic processes.

In the context of infectious diseases, how does FCGR2A contribute to host defense mechanisms? 11/02/2022

FCGR2A participates in host defense against infectious diseases by facilitating the recognition and clearance of pathogens through antibody-mediated immune responses.

How does FCGR2A contribute to the understanding of immunogenetics? 05/26/2021

FCGR2A contributes to the understanding of immunogenetics by highlighting the genetic factors that influence immune responses and the development of immune-related diseases.

How can genetic variations in FCGR2A impact an individual's response to immunotherapy? 03/10/2020

Genetic variations in FCGR2A can influence an individual's response to immunotherapy by affecting the affinity of FCGR2A for antibodies, thereby modulating immune cell activation.

In what ways can FCGR2A be targeted for therapeutic interventions? 12/11/2017

FCGR2A can be targeted for therapeutic interventions through the development of drugs that modulate its activity, offering potential strategies for treating immune-related disorders.

Customer Reviews (3)

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03/22/2023

    With its purity and reliability, this protein is poised to contribute significantly to the success of my research objectives by providing accurate and reproducible results.

    02/26/2023

      Its versatility allows for exploration of its extensive involvement in various biochemical and biological processes, providing valuable insights into its role and implications.

      07/24/2017

        The FCGR2A Protein demonstrates remarkable stability and functional efficiency, making it an indispensable tool for diverse scientific applications.

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