Recombinant Human DLL4 protein, Fc-tagged
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|Product Overview :||Recombinant Human DLL4 (Ser27-Pro524) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).|
|Description :||Delta-like protein 4 (DLL4) is also known as Drosophila Delta homolog 4 (Delta4). DLL4 contains one DSL domain and eight EGF-like domains. DLL4 is expressed in vascular endothelium. DLL4 involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. DLL4 plays a role in the Notch signaling pathway. DLL4 activates Notch-1 and Notch-4.|
|Tag :||human IgG1 Fc|
|Predicted N Terminal :||Ser27|
|Form :||Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.|
|Molecular Mass :||The protein has a calculated MW of 81 kDa. The protein migrates as 95-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Protein length :||Ser27-Pro524|
|Endotoxin :||Less than 1.0 EU per μg by the LAL method.|
|Purity :||>95% as determined by SDS-PAGE.|
For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|SDS-PAGE of DLL4-686H :||
Human DLL4, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
|Gene Name :||DLL4|
|Official Symbol :||DLL4|
|Synonyms :||DLL4; delta-like 4 (Drosophila); delta like 4 homolog (Drosophila); delta-like protein 4; delta4; delta 4; delta ligand 4; notch ligand DLL4; delta-like 4 homolog; delta-like 4 protein; notch ligand delta-2; drosophila Delta homolog 4; hdelta2; MGC126344|
|Gene ID :||54567|
|mRNA Refseq :||NM_019074|
|Protein Refseq :||NP_061947|
|UniProt ID :||Q9NR61|
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