Expand Expand| Cat. No. : | IL12B -177H |
| Product Overview : | Recombinant human IL-12 p40 is a 40 kDa protein containing 306 amino acid residues. It was expressed in E.Coli. |
| Description : | Interleukin-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23. |
| Source : | E.Coli. |
| Purity : | > 95% by SDS-PAGE and HPLC analysis. |
| Endotoxin Level : | < 0.1 ng per μg of IL-12p40. |
| Stabilizer : | None. |
| Formulation : | Lyophilized. |
| Biological Activity : | Not available. |
| Reconstitution : | The human IL-12p40 should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C. |
| Stability : | The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted human IL-12p40 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles. |
| Gene Name : | IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [ Homo sapiens ] |
| Synonyms : | OTTHUMP00000160820; CLMF; CLMF2; IL-12B; NKSF; NKSF2; CLMF p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 subunit p40; IL12, subunit p40; NK cell stimulatory factor chain 2; cytotoxic lymphocyte maturation factor 2, p40; interleukin 12, p40; interleukin 12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); IL12B |
| Gene ID : | 3593 |
| mRNA Refseq : | NM_002187 |
| Protein Refseq : | NP_002178 |
| MIM : | 161561 |
| UniProt ID : | P29460 |
| Chromosome Location : | 5q31.1-q33.1 |
| Pathway : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Toll-like receptor signaling pathway; Type I diabetes mellitus |
| Function : | contributes_to cytokine activity; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-12 alpha subunit binding; interleukin-12 receptor binding; protein binding; protein heterodimerization activity; protein homodimerization activity; signal transducer activity |
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