Expand Expand| Cat. No. : | TNFRSF14-945H |
| Product Overview : | Recombinant human HVEM-Fc Chimera produced inInsect cellsis a 376 amino acid fusion protein containing an N-terminal domain corresponding to the extracellular region of HVEM and a C-terminal domain corresponding to residues 102 to 330 of human IgG1. |
| Description : | HVEM belongs to the TNF Receptor superfamily of transmembrane proteins and plays a role in the activation of T-cells and other lymphocytes. It is expressed in various cells and tissues including spleen, thymus, lung, macrophages, and T-cells. HVEM activation induces a signaling cascade which results in induction of transcription factors NF-kappaB and AP-1. LIGHT (TNFSF14) and TNF-beta (TNFSF1) function as the ligands for HVEM, which can also bind specifically to herpes simplex virus glycoprotein D. Soluble HVEM can act as a “receptor decoy” resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-beta. |
| Source : | Insect cells. |
| Purity : | > 98%, by SDS-PAGE and HPLC analysis. |
| Endotoxin Level : | < 0.1 ng per μg sHVEM/Fc. |
| Stabilizer : | None. |
| Formulation : | Lyophilized. |
| Biological Activity : | Determined by its ability to neutralize 0.25 ng/ml of hTNFβ induced cytotoxicity on murine L929 cells. The expected ED50for this effect is 1.3-1.9 μg/ml of HVEM-Fc. |
| Stability : | The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted HVEM-Fc is stable for at least 3 months when stored in working aliquots with a carrier protein at -20℃. Avoid repeated freeze-thaw cycles. |
| nullValue_other : | Cytokine-cytokine receptor interaction; Signaling in Immune system |
| Gene Name : | TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) [ Homo sapiens ] |
| Synonyms : | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); TR2; ATAR; HVEA; HVEM; LIGHTR; TNFRSF14; tumor necrosis factor receptor superfamily, member 14; CD40-like protein; herpesvirus entry mediator A; tumor necrosis factor receptor-like gene2; OTTHUMP00000000866; Herpesvirus entry mediator A; Tumor necrosis factor receptor-like 2 |
| Gene ID : | 8764 |
| mRNA Refseq : | NM_003820 |
| Protein Refseq : | NP_003811 |
| MIM : | 602746 |
| UniProt ID : | Q92956 |
| Chromosome Location : | 1p36.3-p36.2 |
| Function : | tumor necrosis factor receptor activity; transmembrane receptor activity; protein binding |
Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.
Download Datasheet
See All TNFRSF14 Products
Download Datasheet