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| Cat. No.: | TNFRSF14-945H |
| Product Overview: | Recombinant human HVEM-Fc Chimera produced inInsect cellsis a 376 amino acid fusion protein containing an N-terminal domain corresponding to the extracellular region of HVEM and a C-terminal domain corresponding to residues 102 to 330 of human IgG1. |
| Description: | HVEM belongs to the TNF Receptor superfamily of transmembrane proteins and plays a role in the activation of T-cells and other lymphocytes. It is expressed in various cells and tissues including spleen, thymus, lung, macrophages, and T-cells. HVEM activation induces a signaling cascade which results in induction of transcription factors NF-kappaB and AP-1. LIGHT (TNFSF14) and TNF-beta (TNFSF1) function as the ligands for HVEM, which can also bind specifically to herpes simplex virus glycoprotein D. Soluble HVEM can act as a “receptor decoy” resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-beta. |
| Source: | Insect cells. |
| Purity: | > 98%, by SDS-PAGE and HPLC analysis. |
| Endotoxin Level: | < 0.1 ng per μg sHVEM/Fc. |
| Stabilizer: | None. |
| Formulation: | Lyophilized. |
| Biological Activity: | Determined by its ability to neutralize 0.25 ng/ml of hTNFβ induced cytotoxicity on murine L929 cells. The expected ED50for this effect is 1.3-1.9 μg/ml of HVEM-Fc. |
| Stability: | The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted HVEM-Fc is stable for at least 3 months when stored in working aliquots with a carrier protein at -20℃. Avoid repeated freeze-thaw cycles. |
| nullValue_other: | Cytokine-cytokine receptor interaction; Signaling in Immune system |
| Gene Name: | TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) [ Homo sapiens ] |
| Synonyms: | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); TR2; ATAR; HVEA; HVEM; LIGHTR; TNFRSF14; tumor necrosis factor receptor superfamily, member 14; CD40-like protein; herpesvirus entry mediator A; tumor necrosis factor receptor-like gene2; OTTHUMP00000000866; Herpesvirus entry mediator A; Tumor necrosis factor receptor-like 2 |
| Gene ID: | 8764 |
| mRNA Refseq: | NM_003820 |
| Protein Refseq: | NP_003811 |
| MIM: | 602746 |
| UniProt ID: | Q92956 |
| Chromosome Location: | 1p36.3-p36.2 |
| Function: | tumor necrosis factor receptor activity; transmembrane receptor activity; protein binding |
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