Coactosin-like protein


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Coactosin-like protein

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Cat. No. : CBCRY15
Background : Human coactosin-like protein is an actin filament binding protein but does not bind to globular actin. It associates with 5-Lipoxygenase both in vivo and in vitro, playing important roles in modulating the activities of actin and 5-Lipoxygenase. Coactosin counteracts the capping activity of capping protein which inhibits the actin polymerization. The structure showed a high level of similarity to ADF-H domain, although their amino acid sequences share low degree of homology. A few conserved hydrophobic residues that may contribute to the folding were identified. This structure suggests coactosin-like protein bind to F-actin in a different way from ADF/Cofilin family. Combined with the information from previous mutagenesis studies, the binding sites for F-actin and 5-Lipoxygenase were analyzed, respectively. These two sites are quite close, which might prevent F-actin and 5-Lipoxygenase from binding to coactosin simultaneously.
Protein Classification : protein binding
Structure Weight : 31763.60 Da
Polymer : 1
Molecule : Coactosin-like protein
Chain Length : 145 amino acids
MMDB ID : 30298
Source : E.coli
Method : X-Ray Diffraction
Resolution : 2.8 Å
Reference : Liu, L., Wei, Z., Wang, Y., Wan, M., Cheng, Z., Gong, W.(2004) Crystal Structure of Human Coactosin-like ProteinJ.Mol.Biol.344: 317-323
Gene Name : COTL1
Synonyms : CLP; FLJ43657; MGC19733; coactosin-like 1; coactosin-like 1 (Dictyostelium)
UniProt ID : Q14019
Gene ID : 23406
Chromosome Location : 16q24.1
Function : actin binding; protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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