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Coactosin-like protein

Cat. No.: CBCRY15
Background: Human coactosin-like protein is an actin filament binding protein but does not bind to globular actin. It associates with 5-Lipoxygenase both in vivo and in vitro, playing important roles in modulating the activities of actin and 5-Lipoxygenase. Coactosin counteracts the capping activity of capping protein which inhibits the actin polymerization. The structure showed a high level of similarity to ADF-H domain, although their amino acid sequences share low degree of homology. A few conserved hydrophobic residues that may contribute to the folding were identified. This structure suggests coactosin-like protein bind to F-actin in a different way from ADF/Cofilin family. Combined with the information from previous mutagenesis studies, the binding sites for F-actin and 5-Lipoxygenase were analyzed, respectively. These two sites are quite close, which might prevent F-actin and 5-Lipoxygenase from binding to coactosin simultaneously.
Protein Classification: protein binding
Structure Weight: 31763.60 Da
Polymer: 1
Molecule: Coactosin-like protein
Chain Length: 145 amino acids
PDB ID: 1T2L
MMDB ID: 30298
Source: E.coli
Method: X-Ray Diffraction
Resolution: 2.8 Å
Reference: Liu, L., Wei, Z., Wang, Y., Wan, M., Cheng, Z., Gong, W.(2004) Crystal Structure of Human Coactosin-like ProteinJ.Mol.Biol.344: 317-323
Gene Name: COTL1
Synonyms: CLP; FLJ43657; MGC19733; coactosin-like 1; coactosin-like 1 (Dictyostelium)
UniProt ID: Q14019
Gene ID: 23406
Chromosome Location: 16q24.1
Function: actin binding; protein binding

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