Coactosin-like protein CBCRY15

Coactosin-like protein

PRODUCTS

Home / Products / Others / Coactosin-like protein

Coactosin-like protein

COTL1 Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat. No. : CBCRY15
Background : Human coactosin-like protein is an actin filament binding protein but does not bind to globular actin. It associates with 5-Lipoxygenase both in vivo and in vitro, playing important roles in modulating the activities of actin and 5-Lipoxygenase. Coactosin counteracts the capping activity of capping protein which inhibits the actin polymerization. The structure showed a high level of similarity to ADF-H domain, although their amino acid sequences share low degree of homology. A few conserved hydrophobic residues that may contribute to the folding were identified. This structure suggests coactosin-like protein bind to F-actin in a different way from ADF/Cofilin family. Combined with the information from previous mutagenesis studies, the binding sites for F-actin and 5-Lipoxygenase were analyzed, respectively. These two sites are quite close, which might prevent F-actin and 5-Lipoxygenase from binding to coactosin simultaneously.
Protein Classification : protein binding
Structure Weight : 31763.60 Da
Polymer : 1
Molecule : Coactosin-like protein
Chain Length : 145 amino acids
PDB ID : 1T2L
MMDB ID : 30298
Source : E.coli
Method : X-Ray Diffraction
Resolution : 2.8 Å
Reference : Liu, L., Wei, Z., Wang, Y., Wan, M., Cheng, Z., Gong, W.(2004) Crystal Structure of Human Coactosin-like ProteinJ.Mol.Biol.344: 317-323
Gene Name : COTL1
Synonyms : CLP; FLJ43657; MGC19733; coactosin-like 1; coactosin-like 1 (Dictyostelium)
UniProt ID : Q14019
Gene ID : 23406
Chromosome Location : 16q24.1
Function : actin binding; protein binding

Online Inquiry


  • Note: There will be extra charge for optional service!
  • Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2007 – 2020 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy