Active Recombinant Human Superoxide Dismutase 1, Soluble, His-tagged

• Cat.No.: SOD1-326H

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Cu/Zn Superoxide Dismutase (Cu/Zn SOD) catalyzes the dismutation of superoxide radicals to molecular oxygen. It has been implicated in cellular aging due to its reduced activity in aging cells. Cu/Zn SOD plays a protective role in the pathogenesis of selective neuronal injury after brief ischemia and reduces the degree of necrotic and DNA fragmented neuronal death following global ischemia. Mutant forms of Cu/Zn SOD have been linked to neurodegenerative diseases such as amyotrophic lateral sclerosis.
• Usage: For in vitro use only.
• Form: Liquid. Supplied in 50 mM sodium citrate buffer pH 5.5, 1 mM DTT, 200 μM ZnSO4, and 200 μM CuSO4.
• Activity: > 2.000 units/mg (One unit is defined as the amount of enzyme that will double the rate of autoxidation of 5, 6, 6a, 11b-tetrahydro- 3, 9,10-trihydroxybenzo-[c]- fluorene per minute at 37°C, pH 8.8).
• Purity: > 90% by SDS-PAGE.
• Storage: Quality guaranteed for 12 months, Store at -80°C. Avoid freeze / thaw cycles.
• Publications:
  Superoxide Dismutase 1 Regulation of CXCR4-Mediated Signaling in Prostate Cancer Cells is Dependent on Cellular Oxidative State (2015)

Gene Information

• Gene Name: SOD1 superoxide dismutase 1, soluble [ Homo sapiens ]
• Synonyms: SOD1; superoxide dismutase 1, soluble; ALS; SOD; ALS1; IPOA; homodimer; SOD, soluble; indophenoloxidase A; Cu/Zn superoxide dismutase; superoxide dismutase, cystolic; EC 1.15.1.1; Superoxide dismutase [Cu-Zn]
• Gene ID: 6647
• mRNA Refseq: NM_000454
• Protein Refseq: NP_000445
• MIM: 147450
• UniProt ID: P00441
• Chromosome Location: 21q22.11
• Pathway: Amyotrophic lateral sclerosis (ALS); Huntington"s disease; Prion diseases; Hemostasis
• Function: antioxidant activity; chaperone binding; copper ion binding; metal ion binding; protein homodimerization activity; protein phosphatase 2B binding; superoxide dismutase activity; zinc ion binding