||Cu/Zn Superoxide Dismutase (Cu/Zn SOD) catalyzes the dismutation of superoxide radicals to molecular oxygen. It has been implicated in cellular aging due to its reduced activity in aging cells. Cu/Zn SOD plays a protective role in the pathogenesis of selective neuronal injury after brief ischemia and reduces the degree of necrotic and DNA fragmented neuronal death following global ischemia. Mutant forms of Cu/Zn SOD have been linked to neurodegenerative diseases such as amyotrophic lateral sclerosis.
||For in vitro use only.
||Liquid. Supplied in 50 mM sodium citrate buffer pH 5.5, 1 mM DTT, 200 μM ZnSO4, and 200 μM CuSO4.
||> 2.000 units/mg (One unit is defined as the amount of enzyme that will double the rate of autoxidation of 5, 6, 6a, 11b-tetrahydro- 3, 9,10-trihydroxybenzo-[c]- fluorene per minute at 37°C, pH 8.8).
||> 90% by SDS-PAGE.
||Quality guaranteed for 12 months, Store at -80°C. Avoid freeze / thaw cycles.