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Neurotrophic Factor Artemin Isoform 3

Cat. No.: CBCRY32
Background: Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. Here we report the 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3, which is the initiating step in the formation of a ternary signaling complex containing the shared RET.
Protein Classification: Hormone/growth Factor
Structure Weight: 11574.40 Da
Polymer: 1
Molecule: neurotrophic factor artemin isoform 3
Chain Length: 105 amino acids
PDB ID: 2GYZ
MMDB ID: 40051
Source: E.coli
Method: X-Ray Diffraction
Resolution: 1.76Å
Reference: Wang, X., Baloh, R.H., Milbrandt, J., Garcia, K.C. (2006) Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure 14: 1083-1092
Gene Name: ARTN
Synonyms: ENOVIN; EVN; NBN; OTTHUMP00000009173; OTTHUMP00000009174; neublastin; neurotrophic factor; neurotrophic factor artemin
UniProt ID: Q5T4W7
Gene ID: 9048
Chromosome Location: 1p33-p32
Function: growth factor activity; receptor binding

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