Neurotrophic Factor Artemin Isoform 3

• Cat.No.: CBCRY32

Specification

• Cat. No.: CBCRY32
• Background: Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. Here we report the 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3, which is the initiating step in the formation of a ternary signaling complex containing the shared RET.
• Protein Classification: Hormone/growth Factor
• Structure Weight: 11574.40 Da
• Polymer: 1
• Molecule: neurotrophic factor artemin isoform 3
• Chain Length: 105 amino acids
• PDB ID: 2GYZ
• MMDB ID: 40051
• Source: E.coli
• Method: X-Ray Diffraction
• Resolution: 1.76Å
• Reference: Wang, X., Baloh, R.H., Milbrandt, J., Garcia, K.C. (2006) Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure 14: 1083-1092

Gene Information

• Gene Name: ARTN
• Synonyms: ENOVIN; EVN; NBN; OTTHUMP00000009173; OTTHUMP00000009174; neublastin; neurotrophic factor; neurotrophic factor artemin
• UniProt ID: Q5T4W7
• Gene ID: 9048
• Chromosome Location: 1p33-p32
• Function: growth factor activity; receptor binding