Peroxisome Proliferator-activated Receptor Gamma
Cat.No. : | CBCRY34 |
- Specification
- Gene Information
- Related Products
Cat. No. : | CBCRY34 |
Background : | PPARG regulates fatty acid storage and glucose metabolism. Many insulin sensitizing drugs used in the treatment of diabetes target PPARG as a means to lower serum glucose without increasing pancreatic insulin secretion. The genes activated by PPARG stimulate lipid uptake and adipogenesis by fat cells. PPARG knockout mice fail to generate adipose tissue when fed a high fat diet. |
Protein Classification : | transcription |
Structure Weight : | 34246.95 Da |
Polymer : | 1 |
Molecule : | Peroxisome proliferator-activated receptor gamma |
Chain Length : | 296 amino acids |
PDB ID : | 3BC5 |
MMDB ID : | 67970 |
Source : | E.coli |
Method : | X-Ray Diffraction |
Resolution : | 2.27Å |
Ligand Chemical Component : | ZAA |
Reference : | Zhang, H., Ryono, D.E., Devasthale, P., Wang, W., O`Malley, K., Farrelly, D., Gu, L., Harrity, T., Cap, M., Chu, C., Locke, K., Zhang, L., Lippy, J., Kunselman, L., Morgan, N., Flynn, N., Moore, L., Hosagrahara, V., Zhang, L., Kadiyala, P., Xu, C., Doweyko, A.M., Bell, A., Chang, C., Muckelbauer, J., Zahler, R., Hariharan, N., Cheng, P.T.(2009) Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists. Bioorg.Med.Chem.Lett. 19: 1451-1456 |
Gene Name : | PPARG |
Synonyms : | CIMT1; NR1C3; PPARG1; PPARG2; PPAR-gamma; HUMPPARG; OTTHUMP00000185030; OTTHUMP00000185033; OTTHUMP00000185037; PPAR gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferative activated receptor gamma; peroxisome proliferator-activated receptor gamma 1; nuclear receptor subfamily 1 group C member 3 |
UniProt ID : | P37231 |
Gene ID : | 5468 |
Chromosome Location : | 3p25 |
Function : | arachidonic acid binding; drug binding; metal ion binding; prostaglandin receptor activity; protein heterodimerization activity; retinoid X receptor binding; steroid hormone receptor activity; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
PPARG-4253R | Recombinant Rat PPARG Protein, His (Fc)-Avi-tagged | +Inquiry |
PPARG-3355R | Recombinant Rhesus Macaque PPARG Protein, His (Fc)-Avi-tagged | +Inquiry |
PPARG-4935H | Recombinant Human PPARG Protein, His-tagged | +Inquiry |
Pparg-1961M | Recombinant Mouse Pparg Protein, His-tagged | +Inquiry |
PPARG-2602H | Recombinant Human PPARG Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
PPARG-492HCL | Recombinant Human PPARG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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