Peroxisome Proliferator-activated Receptor Gamma CBCRY34

Peroxisome Proliferator-activated Receptor Gamma

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Peroxisome Proliferator-activated Receptor Gamma

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Cat. No. : CBCRY34
Background : PPARG regulates fatty acid storage and glucose metabolism. Many insulin sensitizing drugs used in the treatment of diabetes target PPARG as a means to lower serum glucose without increasing pancreatic insulin secretion. The genes activated by PPARG stimulate lipid uptake and adipogenesis by fat cells. PPARG knockout mice fail to generate adipose tissue when fed a high fat diet.
Protein Classification : transcription
Structure Weight : 34246.95 Da
Polymer : 1
Molecule : Peroxisome proliferator-activated receptor gamma
Chain Length : 296 amino acids
PDB ID : 3BC5
MMDB ID : 67970
Source : E.coli
Method : X-Ray Diffraction
Resolution : 2.27Å
Ligand Chemical Component : ZAA
Reference : Zhang, H., Ryono, D.E., Devasthale, P., Wang, W., O`Malley, K., Farrelly, D., Gu, L., Harrity, T., Cap, M., Chu, C., Locke, K., Zhang, L., Lippy, J., Kunselman, L., Morgan, N., Flynn, N., Moore, L., Hosagrahara, V., Zhang, L., Kadiyala, P., Xu, C., Doweyko, A.M., Bell, A., Chang, C., Muckelbauer, J., Zahler, R., Hariharan, N., Cheng, P.T.(2009) Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists. Bioorg.Med.Chem.Lett. 19: 1451-1456
Gene Name : PPARG
Synonyms : CIMT1; NR1C3; PPARG1; PPARG2; PPAR-gamma; HUMPPARG; OTTHUMP00000185030; OTTHUMP00000185033; OTTHUMP00000185037; PPAR gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferative activated receptor gamma; peroxisome proliferator-activated receptor gamma 1; nuclear receptor subfamily 1 group C member 3
UniProt ID : P37231
Gene ID : 5468
Chromosome Location : 3p25
Function : arachidonic acid binding; drug binding; metal ion binding; prostaglandin receptor activity; protein heterodimerization activity; retinoid X receptor binding; steroid hormone receptor activity; zinc ion binding

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