Caspase-3

• Cat.No.: CBCRY39

Specification

• Cat. No.: CBCRY39
• Background: Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer"s disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
• Protein Classification: hydrolase
• Structure Weight: 114694.18 Da
• Polymer: 1
• Molecule: Caspase-3
• Chain Length: 253 amino acids
• PDB ID: 3DEK
• MMDB ID: 66481
• Source: E.coli
• Method: X-Ray Diffraction
• Resolution: 2.4Å
• Ligand Chemical Component: Cysteinesulfonic acid
• Reference: Du, J.-Q., Wu, J., Zhang, H.-J., Zhang, Y.-H., Qiu, B.-Y., Wu, F., Chen, Y.-H., Li, J.-Y., Nan, F.-J., Ding, J.-P., Li, J. (2008) Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem. 283: 30205-30215

Gene Information

• Gene Name: CASP3
• Synonyms: CPP32; CPP32B; procaspase3; Yama; SCA-1; OTTHUMP00000165054; PARP cleavage protease; SREBP cleavage activity 1; apopain; caspase 3; caspase 3, apoptosis-related cysteine protease; cysteine protease CPP32
• UniProt ID: P42574
• Gene ID: 836
• Chromosome Location: 4q34
• Function: cysteine-type endopeptidase activity; cyclin-depedent protein kinase inhibitor activity; peptidase activity; cysteine-type peptidase activity; hydrolase activity