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Recombinant Human Chemokine (C-C Motif) Ligand 22, His-tagged

Cat. No.: CCL22-112H
Product Overview: Recombinant human CCL22/MDC, fused to His-tag at N-terminus, was expressed as insoluble protein aggregate inE.coliand purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. MW =10.3 kDa (90aa).
Description: CCL22/MDC is a small cytokine belonging to the CC chemokine family.This protien displays chemotactic activity for natural killer cells, chronically activated T lymphocytes, monocytes and dendritic cells. It interacts with cell surface chemokine receptors CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology.
Source: E.coli.
Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGPYGANMED SVCCRDYVRY RLPLRVVKHF YWTSDSCPRP GVVLLTFRDK EICADPRVPW VKMILNKLSQ
Form: Liquid. In phosphate-buffered Saline(PBS) pH7.4, 10% glycerol.
Purity: > 95% by SDS – PAGE.
Concentration: 0.5 mg/ml (determined by Bradford assay).
Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: CCL22 chemokine (C-C motif) ligand 22 [ Homo sapiens ]
Synonyms: CCL22; chemokine (C-C motif) ligand 22; MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; MGC34554; A-152E5.1; small inducible cytokine A22; CC chemokine STCP-1; macrophage-derived chemokine; stimulated T cell chemotactic protein 1; small inducible cytokine subfamily A (Cys-Cys), member 22; Macrophage-derived chemokine; Small-inducible cytokine A22; Stimulated T-cell chemotactic protein 1; MDC(1-69)
Gene ID: 6367
mRNA Refseq: NM_002990
Protein Refseq: NP_002981
MIM: 602957
UniProt ID: O00626
Chromosome Location: 16q13
Pathway: Chemokine signaling pathway; Cytokine-cytokine receptor interaction
Function: chemokine activity

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