"OAS1" Related Products

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Recombinant Human 2,5-oligoadenylate Synthetase 1, 40/46kDa

Cat. No.: OAS1-378H
Product Overview: Recombinant Human OAS1 protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 43.9 kDa (384aa).
Description: OAS1 is an enzyme included in the 2’,5’-oligoadenylate synthase family. This enzyme is induced by interferons and uses adenosine triphosphate in 2’-specific nucleotidyl transfer reactions to synthesize 2’,5’-oligoadenylates(2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. OAS1 may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis.
Source: E.coli.
Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MMDLRNTPAK SLDKFIEDYL LPDTCFRMQI NHAIDIICGF LKERCFRGSS YPVCVSKVVK GGSSGKGTTL RGRSDADLVV FLSPLTTFQD QLNRRGEFIQ EIRRQLEACQ RERAFSVKFE VQAPRWGNPR ALSFVLSSLQ LGEGVEFDVL PAFDALGQLT GSYKPNPQIY VKLIEECTDL QKEGEFSTCF TELQRDFLKQ RPTKLKSLIR LVKHWYQNCK KKLGKLPPQY ALELLTVYAW ERGSMKTHFN TAQGFRTVLE LVINYQQLCI YWTKYYDFKN PIIEKYLRRQ LTKPRPVILD PADPTGNLGG GDPKGWRQLA QEAEAWLNYP CFKNWDGSPV SSWILLVRPP ASSLPFIPAP LHEA
Form: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol and 1mM DTT.
Purity: > 95% by SDS – PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method ).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: OAS1 2",5"-oligoadenylate synthetase 1, 40/46kDa [ Homo sapiens ]
Synonyms: OAS1; 2",5"-oligoadenylate synthetase 1, 40/46kDa; OIAS; IFI-4; OIASI; 2",5"-oligoadenylate synthetase 1; 2-5A synthetase 1; 2",5"-oligo A synthetase 1; 2"-5"-oligoisoadenylate synthetase 1; 2"-5" oligoadenylate synthetase 1 p48 isoform; 2"-5" oligoadenylate synthetase 1 p52 isoform; EC 2.7.7.-; p46/p42 OAS; E18/E16; OIAS
Gene ID: 4938
mRNA Refseq: NM_001032409
Protein Refseq: NP_001027581
MIM: 164350
UniProt ID: P00973
Chromosome Location: 12q24.2
Function: ATP binding; RNA binding; nucleotide binding; nucleotidyltransferase activity; transferase activity

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