Recombinant Human chemokine (C-X3-C motif) ligand 1, His-tagged CX3CL1-114H

Recombinant Human chemokine (C-X3-C motif) ligand 1, His-tagged

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Recombinant Human chemokine (C-X3-C motif) ligand 1, His-tagged

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Cat. No. : CX3CL1-114H
Product Overview : Recombinant human CX3CL1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW=10.9 kDa (97aa).
Description : CX3CL1, also known as fractalkine. CX3CL1 has a unique CX3C cysteine motif near the amino terminus and is the first member of a fourth branch of the chemokine superfamily. Unlike other known chemokines, CX3CL1 is a type 1 membrane protein containing a chemokine domain tethered on a long mucin like stalk. It is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Also, CX3CL1 elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1.
Source : E. Coli.
Concentration : 0.5 mg/ml (determined by Bradford assay).
Form : Liquid. In Phosphate buffered saline (pH7.4), 10% glycerol.
Purity : > 90% by SDS-PAGE.
Endotoxin Level : < 1.0 EU per 1 μg of protein (determined by LAL method).
Amino Acid Sequence : MGSSHHHHHH SSGLVPRGSH MQHHGVTKCN ITCSKMTSKI PVALLIHYQQ NQASCGKRAI ILETRQHRLF CADPKEQWVK DAMQHLDRQA AALTRNG.
Storage : Can be stored at +4℃ short term (1-2 weeks). For long term storage, aliquot and store at -20℃ or -70℃. Avoid repeated freezing and thawing cycles.
PDB rendering based on 1b2t. :

Gene Name : CX3CL1 chemokine (C-X3-C motif) ligand 1 [ Homo sapiens ]
Synonyms : CX3CL1; chemokine (C-X3-C motif) ligand 1; NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin; small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); C-X3-C motif chemokine 1; Neurotactin; Small-inducible cytokine D1; Processed fractalkine
Gene ID : 6376
mRNA Refseq : NM_002996
Protein Refseq : NP_002987
MIM : 601880
UniProt ID : P78423
Chromosome Location : 16q13
Pathway : Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Signaling by GPCR
Function : chemokine activity

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