Recombinant Human EIF2AK2, GST-tagged, Active

• Cat.No.: EIF2AK2-298H
• Product Overview: Recombinant human EIF2AK2 (252-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=64 kDa.

Specification

• Cat. No.: EIF2AK2-298H
• Description: EIF2AK2 (also known as double-stranded RNA-activated protein kinase) is a protein kinase that has been shown to be involved in HIV/gp120-associated neurodegeneration. EIF2AK2 acts as a critical mediator of gp120 neurotoxicity and is a substrate for a family of protein kinases that respond to various forms of environmental stress. Activation of EIF2AK2 leads to its autophosphorylation and then phosphorylation of its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor-2. EIF2AK2 plays a critical role in mRNA translation, cell proliferation and apoptosis. A novel cross-talk between the EIF2AKs and p53 has been shown that has implications in cell proliferation and tumorigenesis.
• Source: Sf9 insect cellsusing baculovirus.
• Sequence: 252-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 [ Homo sapiens ]
• Synonyms: EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2; OTTHUMP00000201320; double stranded RNA activated protein kinase; interferon-inducible elF2alpha kinase; protein kinase, interferon-inducible double stranded RNA dependent; EC 2.7.11.1
• Gene ID: 5610
• mRNA Refseq: NM_001135651
• Protein Refseq: NP_001129123
• MIM: 176871
• UniProt ID: P19525
• Chromosome Location: 2p22-p21
• Pathway: Influenza Infection
• Function: ATP binding;double-stranded RNA binding; eukaryotic translation initiation factor 2alpha kinase activity; nucleotide binding; protein binding; protein phosphatase type 2A regulator activity; transferase activity