Recombinant Human GSK3B protein, GST-tagged

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Recombinant Human GSK3B protein, GST-tagged

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Cat.No. : GSK3B-326H
Product Overview : Recombinant Human GSK3B fused with GST tag at N-terminal was expressed in Insect cells.
Description : GSK3β is a serine threonine protein kinase that was originally identified as the kinase that phosphorylate and inhibits glycogen synthase. GSK3β is ubiquitously present in human tissues and implicated in the regulation of several physiological processes, including the control of glycogen and protein synthesis by insulin, modulation of the transcription factors AP-1 and CREB. Transient transfection of human GSK3 beta into Chinese hamster ovary cells stably transfected with individual human tau isoforms leads to hyperphosphorylation of tau at all the sites investigated with phosphorylation-dependent anti-tau antibodies.
Source : Insect cells
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Bio-activity : 187 nmol/min/mg
Molecular Mass : ~73 kDa
Purity : > 90%
Applications : Kinase Assay, Western Blot
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 ug/ul
Gene Name : GSK3B glycogen synthase kinase 3 beta [ Homo sapiens ]
Official Symbol : GSK3B
Synonyms : GSK3B; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B;
Gene ID : 2932
mRNA Refseq : NM_002093
Protein Refseq : NP_002084
MIM : 605004
UniProt ID : P49841
Chromosome Location : 3q13.3
Pathway : AKT phosphorylates targets in the cytosol, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Aurora A signaling, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem;
Function : ATP binding; NF-kappaB binding; RNA polymerase II transcription factor binding; beta-catenin binding; kinase activity; nucleotide binding; p53 binding; protein binding; protein kinase A catalytic subunit binding; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity; ubiquitin protein ligase binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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