"HCK" Related Products

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Recombinant Human Hemopoietic Cell Kinase, GST-tagged, Active

Cat. No.: HCK-327H
Product Overview: Recombinant human HCK (230-497) was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=57kDa.
Description: HCK, a protein-tyrosine kinase belonging to the Src family, is expressed in certain hemopoietic cells and especially prominent in cells of myeloid lineage, particularly mature granulocytes and monocytes. HCK gene is located on chromosome sequence 20q11-q12, a region that is affected by interstitial deletions in some acute myeloid leukemias and myeloproliferative disorders suggesting damage to HCK may contribute to the pathogenesis of these conditions.
Source: Sf9 insect cells using baculovirus.
Sequence: 230-497.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: HCK hemopoietic cell kinase [ Homo sapiens ]
Synonyms: HCK; hemopoietic cell kinase; JTK9; Tyrosine-protein kinase HCK; EC 2.7.10.2; Hemopoietic cell kinase; p59-HCK/p60-HCK
Gene ID: 3055
mRNA Refseq: NM_002110
Protein Refseq: NP_002101
UniProt ID: P08631
Chromosome Location: 20q11-q12
MIM: 142370
Pathway: Chemokine signaling pathway; Fc gamma R-mediated phagocytosis; HIV Infection
Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; transferase activity

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