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Recombinant Human Insulin Receptor, GST-tagged, Active

Cat. No.: INSR-331H
Product Overview: Recombinant human InsR (1011-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 70 kDa.
Description: InsR is the insulin receptor tyrosine kinase that is involved in insulin signaling. InsR is post-translationally cleaved into two chains, α and β that are covalently linked. Binding of insulin to the InsR stimulates glucose uptake. Insulin receptor signaling helps to maintain fuel homeostasis and prevent diabetes. Studies have shown that a conditional knockout of insulin receptor substrate 2 (IRS2) in mouse pancreas β cells and parts of the brain--including the hypothalamus--increased appetite, lean and fat body mass, linear growth, and insulin resistance that progressed to diabetes. InsR signaling also increases the regeneration of adult β cells and the central control of nutrient homeostasis.
Source: Sf9 insect cells using baculovirus.
Sequence: 1011-end.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: INSR insulin receptor [ Homo sapiens ]
Synonyms: INSR; insulin receptor; HHF5; CD220; EC 2.7.10.1; IR; CD220 antigen; Insulin receptor subunit alpha; Insulin receptor subunit beta
Gene ID: 3643
mRNA Refseq: NM_000208
Protein Refseq: NP_000199
MIM: 147670
UniProt ID: P06213
Chromosome Location: 19p13.3-p13.2
Pathway: Adherens junction; Insulin signaling pathway; Type II diabetes mellitus
Function: 3-phosphoinositide-dependent protein kinase binding; ATP binding; GTP binding; PTB domain binding; SH2 domain binding; insulin binding; insulin receptor activity; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor II binding; insulin-like growth factor receptor binding; lipoic acid binding; manganese ion binding; metal ion binding; nucleotide binding; phosphoinositide 3-kinase binding; protein complex binding; protein phosphatase binding; receptor activity; receptor signaling protein tyrosine kinase activity; transferase activity

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