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Recombinant Human LCK, GST-tagged, Active

Cat.No. : LCK-342H
Product Overview : Recombinant full-length human LCK was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW = 84 kDa.
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Cat. No. : LCK-342H
Description : LCK (p56lck) is a member of the src family of non-receptor tyrosine kinases. It was identified as a gene rearranged and overexpressed in the murine lymphoma LSTRA, most likely as a result of the insertion of Moloney murine leukemia virus DNA immediately adjacent to the gene. Lck behaves as a proto-oncogene and can lead to cell transformation upon activation. A number of human cancer cell lines show overexpression of LCK, pointing to a possible role for this kinase in the initiation and maintenance of the transformed state in human cancers.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : LCK lymphocyte-specific protein tyrosine kinase [ Homo sapiens ]
Synonyms : LCK; lymphocyte-specific protein tyrosine kinase; YT16; p56lck; pp58lck; protein tyrosine kinase; protein tyrosine kinase; protein tyrosine kinase; protein tyrosine kinase; EC 2.7.10.2; LSK; p56-LCK; Lymphocyte cell-specific protein-tyrosine kinase; T cell-specific protein-tyrosine kinase
Gene ID : 3932
mRNA Refseq : NM_001042771
Protein Refseq : NP_001036236
MIM : 153390
UniProt ID : P06239
Chromosome Location : 1p34.3
Pathway : Natural killer cell mediated cytotoxicity; Primary immunodeficiency; T cell receptor signaling pathway; HIV Infection; HIV Infection; Signaling in Immune system
Function : non-membrane spanning protein tyrosine kinase activity; ATP binding; ATPase binding; CD4 receptor binding; CD8 receptor binding; SH2 domain binding; glycoprotein binding; nucleotide binding; phosphoinositide 3-kinase binding; protein C-terminus binding; protein kinase binding; protein serine/threonine phosphatase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does LCK play in the development and maturation of T cells in the thymus? 05/25/2022

LCK plays a vital role in the development and maturation of T cells in the thymus, especially during the processes of positive and negative selection, ensuring the generation of a functional and self-tolerant T-cell repertoire.

Can LCK activity be modulated by pharmacological agents? 02/24/2022

Yes, LCK activity can be modulated by several pharmacological agents, including kinase inhibitors like dasatinib, which have been explored for therapeutic purposes in various diseases.

How is LCK activation regulated post-translationally? 01/16/2022

LCK activation is regulated post-translationally through phosphorylation at specific tyrosine residues, with its activity being modulated by both activating and inhibitory phosphorylations.

What is the primary function of LCK in T-cell signaling? 07/16/2021

LCK is a pivotal Src family kinase that plays a crucial role in initiating T-cell receptor (TCR) signaling by phosphorylating key tyrosines on the CD3 and ζ-chains of the TCR complex.

How does LCK interact with other kinases in T-cell signaling pathways? 07/08/2020

LCK interacts with other kinases such as ZAP-70 and Fyn in T-cell signaling pathways, orchestrating a cascade of phosphorylation events that lead to T-cell activation.

Are there any known diseases or conditions associated with LCK dysregulation? 12/01/2018

Dysregulation of LCK has been associated with various conditions, including autoimmune diseases, immunodeficiencies, and certain leukemias.

How does LCK contribute to T-cell receptor (TCR) complex formation and activation? 08/14/2018

LCK contributes to TCR complex formation and activation by phosphorylating the immunoreceptor tyrosine-based activation motifs (ITAMs) on the TCR, facilitating the recruitment and activation of ZAP-70 kinase.

Customer Reviews (3)

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Reviews
04/24/2022

    Good stability, long shelf-life.

    10/29/2020

      Consistent quality across batches.

      03/11/2019

        Pure product, reliable results.

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