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Recombinant Human Serine/Threonine Kinase 10, GST-tagged, Active

Cat. No.: STK10-343H
Product Overview: Recombinant human LOK (1-348) was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW = 65 kDa.
Description: LOK is a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. LOK can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. LOK can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. MEKK1 and LOK have opposing roles in regulating the enhancer element of the IL-2 gene during T-cell activation. While MEKK1 is responsible for the CD28 signalling pathway that activates the CD28 response element, co-expression of LOK attenuates these effects.
Source: Sf9 insect cells using baculovirus.
Sequence: 1-348.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: STK10 serine/threonine kinase 10 [ Homo sapiens ]
Synonyms: STK10; serine/threonine kinase 10;LOK; PRO2729; lymphocyte-oriented kinase; EC 2.7.11.1
Gene ID: 6793
mRNA Refseq: NM_005990
Protein Refseq: NP_005981
MIM: 603919
UniProt ID: O94804
Chromosome Location: 5q35.1
Function: ATP binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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