Recombinant Human Serine/Threonine Kinase 10, GST-tagged, Active

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Recombinant Human Serine/Threonine Kinase 10, GST-tagged, Active

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Cat. No. : STK10-343H
Product Overview : Recombinant human LOK (1-348) was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW = 65 kDa.
Description : LOK is a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. LOK can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. LOK can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. MEKK1 and LOK have opposing roles in regulating the enhancer element of the IL-2 gene during T-cell activation. While MEKK1 is responsible for the CD28 signalling pathway that activates the CD28 response element, co-expression of LOK attenuates these effects.
Source : Sf9 insect cells using baculovirus.
Sequence : 1-348.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDB rendering based on 2j7t. :

Gene Name : STK10 serine/threonine kinase 10 [ Homo sapiens ]
Synonyms : STK10; serine/threonine kinase 10;LOK; PRO2729; lymphocyte-oriented kinase; EC 2.7.11.1
Gene ID : 6793
mRNA Refseq : NM_005990
Protein Refseq : NP_005981
MIM : 603919
UniProt ID : O94804
Chromosome Location : 5q35.1
Function : ATP binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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