"CAMKK1" Related Products

Recombinant Human CAMKK1, GST-tagged, Active

Cat. No.: CAMKK1-269H
Product Overview: Recombinant full-length human CAMKK1 was expressed by baculovirus inSf9insect cells using a N-terminal GST tag. MW = 94 kDa.
Description: CAMKK1 or CAMKKα is a Ca(2+)/calmodulin-dependent protein kinase that activates CaM-kinases I and IV via phosphorylation of their Thr(177) and Thr(196) residues, respectively. Recent studies have shown that the activity of CAMKK1 is decreased upon phosphorylation by cAMP-dependent protein kinase (PKA) The CAMKKalpha has been identified in intact cells as AMPKKs, predicting a significant role for this kinase in regulating AMPK activity in vivo. It has been shown that 2-deoxyglucose- and ionomycin-stimulated AMPK activity is substantially reduced in HeLa cells transfected with small interfering RNAs specific for CAMKKα.
Source: Sf9 insect cells using baculovirus.
Sequence: Full-length.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha [ Homo sapiens ]
Synonyms: CAMKK1; calcium/calmodulin-dependent protein kinase kinase 1, alpha; CAMKKA; MGC34095; DKFZp761M0423; calcium/calmodulin-dependent protein kinase 1 alpha; CAMKK alpha protein; EC; OTTHUMP00000115904; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-KK alpha; CaM-kinase IV kinase; CaM-kinase kinase alpha; CaMKK alpha
Gene ID: 84254
mRNA Refseq: NM_032294
Protein Refseq: NP_115670
MIM: 611411
UniProt ID: Q8N5S9
Chromosome Location: 17p13.2
Pathway: Adipocytokine signaling pathway
Function: ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; nucleotide binding; IEA; transferase activity

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