|Cat. No. :
|Product Overview :
||Recombinant full-length human CDK1 and CyclinA2 were co-expressed by baculovirus inSf9insect cells using an N-terminal GST tag on both proteins.
||CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.
||Sf9 insect cells using baculovirus.
|Molecular Weight :
||~59 kDa and CyclinA2 ~78 kDa.
||Kinase Assay, Western Blot.
|Storage And Stability :
||Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.