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Recombinant Human MINK1, GST-tagged, Active

Cat. No. : MINK1-354H
Product Overview : Recombinant human MINK1 (1-320) was expressed by baculovirus inSf9insect cells using a N-terminal GST tag. MW = 61 kDa.
Description : MINK1 is a member of the germinal center family of kinases that are homologous to the Ste20 family and regulate a wide variety of cellular processes, including cell morphology, cytoskeletal rearrangement, and survival. Overexpression of kinase-dead mutants of MINK1 leads to enhanced cell spreading, actin stress fiber formation, adhesion to extracellular matrix and decreased cell motility and invasion. MINK is activated after Ras induction via a mechanism involving reactive oxygen species and mediates stimulation of p38 MAPK downstream of the Raf/ERK pathway.
Source : Sf9 insect cells using baculovirus.
Sequence : 1-320.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : MINK1 misshapen-like kinase 1 (zebrafish) [ Homo sapiens ]
Synonyms : MINK1; misshapen-like kinase 1 (zebrafish); B55; ZC3; MINK; YSK2; hMINK; MAP4K6; MGC21111; hMINKbeta; GCK family kinase MINK; misshapen/NIK-related kinase; serine/threonine protein kinase; EC 2.7.11.1; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Mitogen-activated protein kinase kinase kinase kinase 6; misshapen-like kinase 1 (zebrafish)
Gene ID : 50488
mRNA Refseq : NM_001024937
Protein Refseq : NP_001020108
MIM : 609426
UniProt ID : Q8N4C8
Chromosome Location : 17p13.2
Function : ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; small GTPase regulator activity; transferase activity

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