"PDGFRA" Related Products


Recombinant Human PDGFRA, GST-tagged, Active

Cat. No. : PDGFRA-384H
Product Overview : Recombinant full-length PDGFRA (550-end) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=95kDa.
Description : PDGFRα (platelet-derived growth factor receptor α) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. Aberrant expression of PDGFRα has been linked to developmental abnormalities in vertebrate models and has been implicated in multiple disease states in humans. There is widespread expression of PDGFRα in renal cell types involved in fibrotic and sclerosing processes. PDGF and its receptor PDGFRα are inducers of fibrosis in the repair phase of inflammatory bowel disease and they may also be involved in the active inflammatory phase.
Source : Sf9 insect cells using baculovirus.
Sequence : 550-end.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : PDGFRA platelet-derived growth factor receptor, alpha polypeptide [ Homo sapiens ]
Synonyms : PDGFRA; platelet-derived growth factor receptor, alpha polypeptide; CD140A; PDGFR2; MGC74795; RHEPDGFRA; Alpha-type platelet-derived growth factor receptor; EC; PDGF-R-alpha; CD140 antigen-like family member A; CD140a antigen
Gene ID : 5156
mRNA Refseq : NM_006206
Protein Refseq : NP_006197
MIM : 173490
UniProt ID : P16234
Chromosome Location : 4q12
Pathway : Calcium signaling pathway; Colorectal cancer; Cytokine-cytokine receptor interaction; Endocytosis; Focal adhesion; Gap junction; Glioma; Pathways in cancer; Regulation of actin cytoskeleton; Signaling by PDGF
Function : ATP binding; nucleotide binding; platelet-derived growth factor alpha-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; protein heterodimerization activity; receptor activity; transferase activity; vascular endothelial growth factor receptor activity

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